Tag Archive for: Bone and joint infections

Epidemiology and Antibiotic Sensitivity Patterns in Pyogenic Bone and Joint Infections in Children

Volume 9 | Issue 1 | January-April 2023 | Page: 07-12 | Amit Sharma, G Nirmal Raj Gopinathan, Garima Sharma, Pallavi Sharma, Sange Negi

DOI- https://doi.org/10.13107/ijpo.2023.v09.i01.149


Authors: Amit Sharma [1] MS Ortho., G Nirmal Raj Gopinathan [2] MS Ortho., Garima Sharma [3] MD Microbiology, Pallavi Sharma [4] MS ObGy., Sange Negi [1] MS Ortho.

[1] Department of Orthopaedics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
[2] Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
[3] Department of Microbiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
[4] Department of Obstetrics and Gynaecology, Government Medical College Hospital, Chandigarh, India.

Address of Correspondence

Dr. Garima Sharma,
Department of Microbiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
E-mail: garimaserene@gmail.com


Abstract

Staphylococcus aureus is the most common organism causing paediatric bone and joint infections accounting for 86% of pus culture-positive cases. Methicillin resistant staphylococcus aureus (MRSA) has become a major challenge in the tertiary care setting as the majority (56%) of all pus culture postive cases were MRSA. The male to female ratio in these infections was approximately 2:1. The lower limbs were affected in the majority of children with osteomyelitis (OM) with hip joint being the commonest (50%) followed by the knee. Broad spectrum antibiotics were used emperically in 40% of cases prior to referral to a tertiary care centre. MRSA infections were associated with a higher likelihood of complications.
Keywords: Paediatric, Pyogenic, Bone and joint infections, Antibiotic practices

References

1. Unkila-Kallio L, Kallio MJ, Peltola H. Acute haematogenous osteomyelitis in children in Finland. Ann Med. 1993, 25:545–49
2. Dahl LB, HLyland AL, Dramsdahl H, Kaaresen Pl. Acute osteomyelitis in children: a population-based retrospective study 1965 to 1994. Scand J Infect Dis. 1998; 30:573-77.
3. McCarthy JJ, Dormans JP, Kozin SH, Pizzutillo PD. Musculoskeletal infections in children. Basic treatment principles and recent advancements. J Bone Joint Surg.2004;86:850-63.
4. Blyth MJG, Kincaid R, Craigen MAC, Bennet GC. The changing epidemiology of acute and subacute haematogenous osteomyelitis in children. J Bone Joint Surg2001;83:99-102.
5. Stanitski CL. Changes in pediatric acute hematogenous osteomyelitis management. J Pediatr Orthop.2004;24:444-45.
6. Goergens ED, McEvoyA,Watson M, Barrett IR. Acute osteomyelitis and septic arthritis in children. J Paediatr Child Health. 2005;41:59-62.
7. Hollmig ST, Copley LA, Browne RH, Grande LM, Wilson PL. Deep venous thrombosis associated with osteomyelitis in children. J Bone Joint Surg. 2007;89:1517-23.
8. Crary SE, Buchanan GR, Drake CE, Journeycake JM . Venous thrombosis and thromboembolism in children with osteomyelitis. J Pediatr. 2006;149:537-41.
9. Van Boeckel T.P., Gandra S., Ashok A., Caudron Q., Grenfell B.T., Levin S.A., et al. Global antibiotic consumption 2000 to 2010: An analysis of national pharmaceutical sales data.Lancet Infect Dis. 2014;14:742–50.
10. Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, et al. Antibiotic resistance-the need for global solutions. The Lancet Infectious Diseases. 2013;13:1057–98.
11. Ganguly NK, Arora NK, Chandy SJ, Fairoze MN, Gill JP, Gupta U, et al. Rationalizing antibiotic use to limit antibiotic resistance in India. Indian J Med Res. 2011;134:281–94.
12. Gordon JE, Wolff A, Luhmann SJ, Ortman MR, Dobbs MB, Schoenecker PL. Primary and delayed closure after open irrigation and debridement of septic arthritis in children. J PediatrOrthopB.2005;14:101-4.
13. Maraqa NF, Gomez MM, Rathore MH. Outpatient parenteral antimicrobial therapy in osteoarticular infections in children. J PediatrOrthop. 2002;22:506-10.
14. Perlman MH, Patzakis MJ, Kumar PJ, Holtom P. The incidence of joint involvement with adjacent osteomyelitis in paediatric patients. J PediatrOrthop. 2000;20:40-3.
15. Shirtliff ME, Mader JT. Acute septic arthritis. ClinMicrobiol Rev 2002;15:527-44.
16. Saavedra-Lozano J, Mejías A, Ahmad N, Peromingo E, Ardura MI, Guillen S, et al. J PediatrOrthop. 2008;28:569-75.
17. Pääkkönen M, Peltola H. Acute osteomyelitis in children. N EnglJMed. 2014;370:1365–66
18. Street M, Puna R , Huang M, Crawford H. . Pediatric acute hematogenous osteomyelitis. J PediatrOrthop. 2015;35:634–39.
19. Kiang KM, Ogunmodede F, Juni BA , Boxrud DJ, Glennen A , Bartkus JM et al. Outbreak of osteomyelitis/septic arthritis caused by Kingellakingae among child care center attendees. Pediatrics. 2005;116:e206–e213.
20. McIntosh N, Helms PJ, Smyth PRL, Logan S. Forfar &Arneil Textbook of Pediatrics. 7th International edition edition. Edinburgh; New York: Churchill Livingstone; 2008. 1808 p.
21. Barker A, Verhoeven K, Ahsan M, Alam S, Sharma P, Sengupta S, et al Id:25: Social Determinants of Patient Antibiotic Misuse in Haryana, India. J Investig Med. 2016; 64:935–935.
22. Yu F, Liu H, Li K, Lei G, Gao S, Chen Y, et al. Causative organisms and their antibiotic resistance patterns for childhood septic arthritis in china between 1989 and 2008. Orthopedics. 2011; 34:179.
23. Emily RD. Osteomyelitis and septic arthritis in children: current concepts.CurrOpinPediatr. 2013; 25:58–63.
24. Khatoon R, Khan SA, Jahan N. Antibiotic resistance pattern among aerobic bacterial isolates from osteomyelitis cases attending a Tertiary care hospital of North India with special reference to ESBL, AmpC, MBL and MRSA production. Int J Res Med Sci. 2017;5:482–90.
25. Kumar SG, Adithan C, Harish BN, Sujatha S, Roy G, Malini A. Antimicrobial resistance in India: A review. J Nat SciBiol Med. 2013;4:286–91.
26. Sukswai P, Kovitvanitcha D, Thumkunanon V, Chotpitayasunondh T, Sangtawesin V, Jeerathanyasakun Y. Acute hematogenous osteomyelitis and septic arthritis in children: clinical characteristics and outcomes study. J Med AssocThailChotmaihetThangphaet. 2011;94:S209-216.
27. Stoesser N, Pocock J, Moore CE, Soeng S, Hor P, Sar P et al. The epidemiology of pediatric bone and joint infections in Cambodia, 2007-11. J Trop Pediatr. 2013;59:36–42.
28. Lavy CB. Septic arthritis in Western and sub-Saharan African children – a review. Int Orthop. 2007 Apr;31(2):137-44. doi: 10.1007/s00264-006-0169-9. Epub 2006 Jun 2. PMID: 16741731; PMCID: PMC2267558.


How to Cite this Article: Sharma A, Gopinathan GNR, Sharma G, Sharma P, Negi S | Epidemiology and Antibiotic Sensitivity Patterns in Pyogenic Bone and Joint Infections in Children | International Journal of Paediatric Orthopaedics | January-April 2023; 9(1): 07-12 | https://doi.org/10.13107/ijpo.2023.v09.i01.149

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