Tag Archive for: Pyomyositis

Introduction to Paediatric Musculoskeletal Infections -A Review Article

Volume 9 | Issue 3 | September-December 2023 | Page: 02-08 | Suresh Chand, Bhushan Sagade, Udit Agarwal, Nishant Jagdale, Smit Rajput

DOI- https://doi.org/10.13107/ijpo.2023.v09.i03.156


Authors: Suresh Chand MS Ortho [1], Bhushan Sagade MS Ortho [2], Udit Agarwal MS Ortho [1], Nishant Jagdale DNB Ortho [2], Smit Rajput MD [3]

[1] Department of Paediatric Orthopaedics, King George’s Medical University, Lucknow, India.
[2] Department of Paediatric Orthopaedics, Bai Jerbai Wadia Hospital for Children, Mumbai, India.
[3] Department of Internal Medicine, East Carolina University and ECU Health Medical Center, Greenville, North Carolina, USA.

Address of Correspondence

Dr. Nishant Jagdale,
Fellow in Paediatric Orthopaedics, Department of Paediatric Orthopaedics, Bai Jerbai Wadia Hospital for Children, Mumbai, India.
E-mail: nishant93ortho@gmail.com


Abstract

Paediatric Musculoskeletal Infections include osteomyelitis, septic arthritis, pyomyositis, surgical site infections, tuberculosis, and fungal infections with some infrequent manifestations like purpura fulminans, necrotizing fasciitis, soft tissue abscess and septic bursitis. Osteomyelitis and septic arthritis are two common Musculoskeletal Infections. Vertebral tuberculosis is the most common form of skeletal tuberculosis. Staphylococcus aureus is the most frequent cause of Paediatric Musculoskeletal Infections, followed by streptococci. They can be classified on the basis of pathogen, anatomical site, spread, severity etc. Pathogenic organisms may reach a bone or soft tissue location by either of the three means: (a) direct inoculation from penetrating trauma or surgery, (b) contiguous spread from an adjacent soft tissue infection, (c) hematogenous spread from a distant focus of infection with hematogenous spread being the most common cause. It is a complex interplay between the host and the pathogen which plays major role in these infections. Peculiar anatomy of the metaphysis with classical hairpin loop system of the end arterioles and venous sinusoids aids in pathogen entry into the host. After successful invasion of the host, bacteria escapes the host immunity through various mechanisms, complement component pathway being the most common way. Also the various toxins and proteins secreted by bacteria plays an important role in adhesion, invasion, escape form immunity and spread of the infection. This review article helps in understanding this complex interplay between host and pathogen which ultimately results in infection

Keywords: Paediatric Musculoskeletal infections, Osteomyelitis, Pyomyositis, Septic Arthritis.


References

1. Trapani S. Musculoskeletal infections in childhood: Recognize early to quickly and properly treat. Glob Pediatr. 2024 Mar 1; 7:100108. doi: 10.1016/j.gpeds.2023.100108
2. Hunter, Sarah & Chan, Heidi & Crawford, et al: (2023). Appropriate Antibiotic Duration in Pediatric Bone and Joint Infection: A Systematic Review. Journal of the Pediatric Orthopaedic Society of North America. 5. doi: 10.55275/JPOSNA-2023-736.
3. Hannon M, Lyons T. Pediatric musculoskeletal infections. Curr Opin Pediatr. 2023 Jun 1;35(3):309–15.
4. Radcliffe G. (iii) Osteomyelitis – a historical and basic sciences review. Orthop Trauma. 2015 Aug 1;29(4):243–52.
5. Klenerman L. A history of osteomyelitis from the Journal of Bone and Joint Surgery: 1948 TO 2006. J Bone Joint Surg Br. 2007 May;89(5):667-70. doi: 10.1302/0301-620X.89B5.19170. PMID: 17540756.
6. Nelaton A.: Elements de pathologie chirurgical1844.Germer BailliereParispp. 595-597
7. Schmitt SK. Osteomyelitis. Infect Dis Clin North Am. 2017 Jun;31(2):325-338. doi: 10.1016/j.idc.2017.01.010. PMID: 28483044.
8. Ahmad S, Barik S, Mishra D, et al: Epidemiology of paediatric pyogenic musculoskeletal infections in a developing country. Sudan J Paediatr. 2022;22(1):54-60. doi: 10.24911/SJP.106-1616783478. PMID: 35958066.
9. Jaña FC NETO, Ortega CS, Goiano EO. Epidemiological study of osteoarticular infections in children. Acta Ortop Bras. 2018 May-Jun;26(3):201-205. doi: 10.1590/1413-785220182603145650. PMID: 30038548.
10. Shah I, Dani S, Shetty NS, et al: Profile of osteoarticular tuberculosis in children. Indian J Tuberc. 2020 Jan;67(1):43-45. doi: 10.1016/j.ijtb.2019.08.014. Epub 2019 Aug 22. PMID: 32192616.
11. Jain AK, Jaggi KR, Bhayana H, et al: Drug-resistant Spinal Tuberculosis. Indian J Orthop. 2018 Mar-Apr;52(2):100-107. doi: 10.4103/ortho.IJOrtho_306_17. PMID: 29576636.
12. Mohamad M, Steiger C, Spyropoulou V, et al: Clinical, biological and bacteriological characteristics of osteoarticular infections in infants less than 12 months of age. Future Microbiol. 2021 Apr;16:389-397. doi: 10.2217/fmb-2020-0070. Epub 2021 Apr 13. PMID: 33847142.
13. Shenoy B, Singhal T, Yewale V, et al: Indian Academy of Pediatrics Consensus Statement on Diagnosis and Management of Bone and Joint Infections in Children. INDIAN Pediatr. 2024;61.
14. Agarwal A, Aggarwal AN. Bone and Joint Infections in Children: Septic Arthritis. Indian J Pediatr. 2016 Aug;83(8):825-33. doi: 10.1007/s12098-015-1816-1. Epub 2015 Jul 21. PMID: 26189923.
15. Saavedra-Lozano J, Falup-Pecurariu O, Faust SN, et al: Bone and Joint Infections. Pediatr Infect Dis J. 2017 Aug;36(8):788-799. doi: 10.1097/INF.0000000000001635. PMID: 28708801.
16. Le Saux N. Diagnosis and management of acute osteoarticular infections in children. Paediatr Child Health. 2018 Aug;23(5):336-343. doi: 10.1093/pch/pxy049. Epub 2018 Jul 18. PMID: 30653632; PMCID: PMC6054183.
17. Morrey BF, Peterson HA. Hematogenous pyogenic osteomyelitis in children. Orthop Clin North Am. 1975 Oct;6(4):935-51. PMID: 1178165.
18. Hatzenbuehler J, Pulling TJ. Diagnosis and management of osteomyelitis. Am Fam Physician. 2011 Nov 1;84(9):1027-33. PMID: 22046943.
19. Roderick MR, Shah R, Rogers V, et al: Chronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis. Pediatr Rheumatol Online J. 2016 Aug 30;14(1):47. doi: 10.1186/s12969-016-0109-1. PMID: 27576444.
20. Vij N, Ranade AS, Kang P, et al: Primary Bacterial Pyomyositis in Children: A Systematic Review. J Pediatr Orthop. 2021 Oct 1;41(9):e849-e854. doi: 10.1097/BPO.0000000000001944. PMID: 34411048.
21. Taksande A, Vilhekar K, Gupta S. Primary pyomyositis in a child. Int J Infect Dis. 2009 Jul;13(4):e149-51. doi: 10.1016/j.ijid.2008.08.013. Epub 2008 Nov 13. PMID: 19013093.
22. Mignemi ME, Benvenuti MA, An TJ, et al: A Novel Classification System Based on Dissemination of Musculoskeletal Infection is Predictive of Hospital Outcomes. J Pediatr Orthop. 2018 May/Jun;38(5):279-286. doi: 10.1097/BPO.0000000000000811. PMID: 27299780.
23. Hotchen AJ, McNally MA, Sendi P. The Classification of Long Bone Osteomyelitis: A Systemic Review of the Literature. J Bone Jt Infect. 2017 Sep 12;2(4):167-174. doi: 10.7150/jbji.21050. PMID: 29119075.
24. Mader JT, Shirtliff M, Calhoun JH. Staging and staging application in osteomyelitis. Clin Infect Dis. 1997 Dec;25(6):1303-9. doi: 10.1086/516149. PMID: 9431368.
25. Stevenson AJ, Jones HW, Chokotho LC, et al: The Beit CURE Classification of Childhood Chronic Haematogenous Osteomyelitis–a guide to treatment. J Orthop Surg Res. 2015 Sep 17;10:144. doi: 10.1186/s13018-015-0282-9. PMID: 26384208
26. McHenry MC, Alfidi RJ, Wilde AH, Hawk WA. Hematogenous osteomyelitis; a changing disease. Cleve Clin Q. 1975 Spring;42(1):125-53. doi: 10.3949/ccjm.42.1.125. PMID: 1095249.
27. Copley L.A.B., Herring J.A., (2014) Infections of the Musculoskeletal System. In J.A. Herring (Ed). Tachdjian’s Paediatric Orthopaedics (5th ed, Vol-2, pp:1024 -1076e10) Elseweir, Saunders
28. Ciampolini J, Harding KG. Pathophysiology of chronic bacterial osteomyelitis. Why do antibiotics fail so often? Postgrad Med J. 2000;76(898):479–83.
29. Moore-Lotridge, S.N., Schoenecker, J.G. (2022). Pathology of Musculoskeletal Infections. In: Belthur, M.V., Ranade, A.S., Herman, M.J., Fernandes, J.A. (eds) Pediatric Musculoskeletal Infections. Springer, Cham. https://doi.org/10.1007/978-3-030-95794-0_3
30. Scheman L.R., Janota M., & Lewin P. The production of experimental osteomyelitis: Preliminary report. JAMA, Nov 1 1941, 117:18, 1525-1529.
31. Hobo T: Zur Pathogenese der akuten hematogenen Osteomyelitis. Acta Sch Me Kioto 1921;4:1.
32. Trueta J. The three types of acute hematogenous osteomyelitis: A clinical and vascular study. J Bone Joint Surg. 1959, 41-B:4, 671-680.
33. Herring J.A., (2002) Bone and Joint Infections. Tachdjian’s Paediatric Orthopaedics (3rd ed, Vol-3, pp:1841 -1894) W.B. Saunders.
34. Ogden JA, Lister G: The pathology of Neonatal osteomyelitis. Pediatrics 1975;56-A:941
35. Whalen JL,Fitzgerald RH Jr, Morrissy RT: A histological study of acute hematogenous osteomyelitis following physeal injury in rabbits. J Bone Joint Surg 1988;70-A:1383
36. Morrissy RT, Haynes DW: Acute Hematogenous Osteomyelitis: A model with trauma as an etiology. J Pediatr Orthop 1989;9:447.
37. Manche E, Rombouts-Godin V, Rombouts JJ: {Acute Hematogenous Osteomyelitis due to ordinary germs in children with closed injuries: a study of 44 cases}.Acta Orthop Belg 1991;57:91
38. Hofstee MI, Muthukrishnan G, Atkins GJ, Riool M, Thompson K, Morgenstern M, Stoddart MJ, Richards RG, Zaat SAJ, Moriarty TF. Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods. Am J Pathol. 2020 Jun;190(6):1151-1163. doi: 10.1016/j.ajpath.2020.02.007. Epub 2020 Mar 16. PMID: 32194053
39. Rosenfeld S, Bernstein DT, Daram S, Dawson J, Zhang W. Predicting the presence of adjacent infections in septic arthritis in children. J Pediatr Orthop. 2016;36(1):70–4.
40. R. Cunningham, A. Cockayne, H. Humphreys. Clinical and molecular aspects of the pathogenesis of Staphylococcus aureus bone and joint infections. J. Med Microbiol. – Vol. 44 (1996), 157-164
41. Flemming H.C., Wingender J., Szewzyk U., Steinberg P., Rice S.A., Kjelleberg S. Biofilms: an emergent form of bacterial life. Nat Rev Microbiol. 2016; 14: 563-575
42. Garzoni C., Kelley W.L. Staphylococcus aureus: new evidence for intracellular persistence. Trends Microbiol. 2009; 17: 59-65
43. Martinez-Aguilar G, Avalos-Mishaan A, Hulten K, et al: Community-acquired, methicillin-resistant and methicillin susceptible Staphylococcus aureus musculoskeletal infections in children, Pediatr Infect Dis J 23:701, 2004
44. Yang D., Wijenayaka A.R., Solomon L.B., Pederson S.M., Findlay D.M., Kidd S.P., Atkins G.J. Novel insights into Staphylococcus aureus deep bone infections: the involvement of osteocytes. mBio. 2018; 9: e00415-e00418
45. Kwiecinski J., Na M., Jarneborn A., Jacobsson G., Peetermans M., Verhamme P., Jin T. Tissue plasminogen activator coating on implant surfaces reduces Staphylococcus aureus biofilm formation. Appl Environ Microbiol. 2016; 82: 394-401
46. Cicuéndez M, Doadrio JC, Hernández A, Portolés MT, Izquierdo-Barba I, Vallet-Regí M. Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection. Acta Biomater. 2018 Jan;65:450-461. doi: 10.1016/j.actbio.2017.11.009. Epub 2017 Nov 8. PMID: 29127064.


How to Cite this Article:  Chand S, Sagade B, Agarwa U, Jagdale N, Rajput S | Introduction to Paediatric Musculoskeletal Infections- A Review Article | International Journal of Paediatric Orthopaedics | September- December 2023; 9(3): 02-08.| https://doi.org/10.13107/ijpo.2023.v09.i03.156

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Paediatric Musculoskeletal Infection– A Review

Volume 9 | Issue 3 | September-December 2023 | Page: 09-15 | Ashish Upadhyay, Varun Garg, Anil Agarwal, Kishmita Sachdeva, Ankitha KS, Jainam Salot

DOI- https://doi.org/10.13107/ijpo.2023.v09.i03.157


Authors: Ashish Upadhyay MS Ortho [1], Varun Garg MS Ortho [1], Anil Agarwal MS Ortho [1], Kishmita Sachdeva MS Ortho [1], Ankitha KS MS Ortho [1], Jainam Salot MS Ortho [1]

[1] Department of Paediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi, India.

Address of Correspondence

Dr. Anil Agarwal,
Department of Orthopedics, Chacha Nehru Bal Chikitsalya, New Delhi, India
E-mail: anilrachna@gmail.com


Abstract

Acute paediatric musculoskeletal infections (MSKI) include septic arthritis, acute osteomyelitis and pyomyositis. Prompt treatment is necessary to prevent long term disabilities in children. In this review, we discuss the etiopathogenesis, clinical features and management of MSKI. We also discuss about the role of new markers of inflammation and MRI in MSKI. The clinical presentation is variable, depending upon the age group, and difficult to distinguish from other pathologies. Diagnosis is therefore based on not only clinical presentation but also laboratory and radiological investigations. The mainstay of treatment includes antibiotic therapy, and surgical decompression.

Keywords: Septic arthritis, Musculoskeletal infections, Osteomyelitis, Pyomyositis


References

1. Saavedra-Lozano J, Falup-Pecurariu O, Faust SN, Girschick H, Hartwig N, Kaplan S, et al. Bone and joint infections. Pediatr Infect Dis J. 2017;36:788–99.
2. Agarwal A, Aggarwal AN. Bone and joint infections in children: acute hematogenous osteomyelitis. Indian J Pediatr. 2016;83:817–24.
3. Calvo C, Núñez E, Camacho M, Clemente D, Fernández-Cooke E, Alcobendas R, et al. Epidemiology and management of acute, uncomplicated septic arthritis and osteomyelitis: Spanish multicenter study. Pediatr Infect Dis J. 2016;35:1288–93.
4. Dartnell J, Ramachandran M, Katchburian M. Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature. J Bone Joint Surg Br. 2012;94:584–95.
5. Samara E, Spyropoulou V, Tabard-Fougère A, Merlini L, Valaikaite R, Dhouib A, et al. Kingella Kingae and osteoarticular infections. Pediatrics. 2019;144:e20191509.
6. Kang SN, Sanghera T, Mangwani J, Paterson JMH, Ramachandran M. The management of septic arthritis in children: systematic review of the English language literature. J Bone Joint Surg Br. 2009;91:1127–33.
7. Gigante A, Coppa V, Marinelli M, Giampaolini N, Falcioni D, Specchia N. Acute osteomyelitis and septic arthritis in children: a systematic review of systematic reviews. Eur Rev Med Pharmacol Sci. 2019 ;23(2 Suppl):145–58.
8. Comegna L, Guidone PI, Prezioso G, Franchini S, Petrosino MI, Di Filippo P, et al. Pyomyositis is not only a tropical pathology: a case series. J Med Case Reports. 2016;10:372.
9. Momodu II, Savaliya V. Septic Arthritis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 May 1]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK538176/
10. Stephen RF, Benson MKD, Nade S. Misconceptions about childhood acute osteomyelitis. J Child Orthop. 2012;6:353–6.
11. Morrissy RT, Haynes DW. Acute hematogenous osteomyelitis: a model with trauma as an etiology. J Pediatr Orthop. 1989;9:447–56.
12. Rosenfeld S, Bernstein DT, Daram S, Dawson J, Zhang W. Predicting the presence of adjacent infections in septic arthritis in children. J Pediatr Orthop. 2016;36:70–4.
13. Benvenuti M, An T, Amaro E, Lovejoy S, Mencio G, Martus J, et al. Double-edged sword: musculoskeletal infection provoked acute phase response in children. Orthop Clin North Am. 2017;48:181–97.
14. Li Y, Zhou Q, Liu Y, Chen W, Li J, Yuan Z, et al. Delayed treatment of septic arthritis in the neonate: A review of 52 cases. Medicine (Baltimore). 2016;95:e5682.
15. Deshpande SS, Taral N, Modi N, Singrakhia M. Changing epidemiology of neonatal septic arthritis. J Orthop Surg Hong Kong. 2004;12:10–3.
16. Narang A, Mukhopadhyay K, Kumar P, Bhakoo ON. Bone and joint infection in neonates. Indian J Pediatr. 1998;65:461–4.
17. Moore-Lotridge SN, Gibson BH, Duvernay MT, Martus JE, Thomsen IP, Schoenecker JG. Pediatric musculoskeletal infection: an update through the four pillars of clinical care and immunothrombotic similarities with COVID-19. J Pediatr Orthop Soc N Am [Internet]. 2020 [cited 2024 May 1];2(2). Available from: https://www.jposna.org/index.php/jposna/article/view/124
18. Mitchell PD, Abraham A, Carpenter C, Henman PD, Mavrotas J, McCaul J, et al. Consensus guidelines on the management of musculoskeletal infection affecting children in the UK. Bone Jt J. 2023;105-B:815–20.
19. Moore-Lotridge SN, Daryoush JR, Wollenman CC, Gibian JT, Johnson SR, Thomsen IP, et al. CRP predicts the need to escalate care after initial debridement for musculoskeletal infection. J Pediatr Orthop. 2024;44:188–96.
20. Benvenuti MA, An TJ, Mignemi ME, Martus JE, Mencio GA, Lovejoy SA, et al. A clinical prediction algorithm to stratify pediatric musculoskeletal infection by severity. J Pediatr Orthop. 2019;39:153–7.
21. Sox HC, Liang MH. The erythrocyte sedimentation rate. Guidelines for rational use. Ann Intern Med. 1986;104:515–23.
22. Böttiger LE, Svedberg CA. Normal erythrocyte sedimentation rate and age. Br Med J. 1967;2(5544):85–7.
23. Wirtz DC, Heller KD, Miltner O, Zilkens KW, Wolff JM. Interleukin-6: a potential inflammatory marker after total joint replacement. Int Orthop. 2000;24:194–6.
24. Whicher J, Bienvenu J, Monneret G. Procalcitonin as an acute phase marker. Ann Clin Biochem. 2001;38:483–93.
25. Oppert M, Reinicke A, Müller C, Barckow D, Frei U, Eckardt KU. Elevations in procalcitonin but not C-reactive protein are associated with pneumonia after cardiopulmonary resuscitation. Resuscitation. 2002;53:167–70.
26. Li H, Luo YF, Blackwell TS, Xie CM. Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections. Antimicrob Agents Chemother. 2011;55:5900.
27. Lowsby R, Gomes C, Jarman I, Lisboa P, Nee PA, Vardhan M, et al. Neutrophil to lymphocyte count ratio as an early indicator of blood stream infection in the emergency department. Emerg Med J. 2015;32:531–4.
28. Gafter-Gvili A, Mansur N, Bivas A, Zemer-Wassercug N, Bishara J, Leibovici L, et al. Thrombocytopenia in Staphylococcus aureus bacteremia: risk factors and prognostic importance. Mayo Clin Proc. 2011;86:389–96.
29. Malpani R, Haynes MS, Clark MG, Galivanche AR, Bovonratwet P, Grauer JN. Abnormally high, as well as low, preoperative platelet counts correlate with adverse outcomes and readmissions after elective total knee arthroplasty. J Arthroplasty. 2019;34:1670–6.
30. Higgins E, Suh GA, Tande AJ. Enhancing diagnostics in orthopedic infections. J Clin Microbiol. 2022;60:e0219621.
31. Li SF, Cassidy C, Chang C, Gharib S, Torres J. Diagnostic utility of laboratory tests in septic arthritis. Emerg Med J. 2007;24:75–7.
32. Kelly EG, Cashman JP. Leucocyte esterase in the rapid diagnosis of paediatric septic arthritis. Med Hypotheses. 2013;80:191–3.
33. Deshpande PG, Wagle SU, Mehta SD, Bharucha BA, Irani SF. Neonatal osteomyelitis and septic arthritis. Indian Pediatr. 1990;27:453–7.
34. Kothari NA, Pelchovitz DJ, Meyer JS. Imaging of musculoskeletal infections. Radiol Clin North Am. 2001;39:653–71.
35. Volberg FM, Sumner TE, Abramson JS, Winchester PH. Unreliability of radiographic diagnosis of septic hip in children. Pediatrics. 1984;74:118–20.
36. Chau CLF, Griffith JF. Musculoskeletal infections: ultrasound appearances. Clin Radiol. 2005;60:149–59.
37. Shenoy B, Singhal T, Yewale V, Choudhury J, Kumar A P, Agashe MV, et al. Indian Academy of Pediatrics consensus statement on diagnosis and management of bone and joint infections in children. Indian Pediatr. 2024;61:209–18.
38. Castellazzi L, Mantero M, Esposito S. Update on the management of pediatric acute osteomyelitis and septic arthritis. Int J Mol Sci. 2016;17:855.
39. Bhaskar AR, Johari AN. Musculoskeletal infections in the neonate. In: Belthur MV, Ranade AS, Herman MJ, Fernandes JA (eds), Pediatric Musculoskeletal Infections. Springer, Cham. 2022.
40. Swarup I, Meza BC, Weltsch D, Jina AA, Lawrence JT, Baldwin KD. Septic arthritis of the knee in children: a critical analysis review. JBJS Rev. 2020;8:e0069.
41. Peters W, Irving J, Letts M. Long-term effects of neonatal bone and joint infection on adjacent growth plates. J Pediatr Orthop. 1992;12:806–10.
42. Kaye JJ, Winchester PH, Freiberger RH. Neonatal septic “dislocation” of the hip: true dislocation or pathological epiphyseal separation? Radiology. 1975 ;114:671–4.
43. Zhang Z, Li H, Li H, et al. Clinical experience of debridement combined with resorbable bone graft substitute mixed with antibiotic in the treatment for infants with osteomyelitis. J Orthop Surg Res. 2018;13:218.


How to Cite this Article:  Upadhyay A, Garg V, Agarwal A, Sachdeva K, Ankitha KS, Salot J. | Paediatric Musculoskeletal Infection– A Review | International Journal of Paediatric Orthopaedics | September-December 2023; 9(3): 09-15. | https://doi.org/10.13107/ijpo.2023.v09.i03.157

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A Case of Pyomyositis in a Healthy 11-Year Old Boy with Need of Surgical Drainage

Volume 8 | Issue 1 | January-April 2022 | Page: 47-50 | Alina Frolova, Joana Freitas, Rui Martins, Jorge Coutinho

DOI-10.13107/ijpo.2022.v08i01.134


Authors: Alina Frolova MD [1], Joana Freitas MD [1], Rui Martins MD [1], Jorge Coutinho MD [1]

[1] Department of Pediatric Orthopedics, The University Hospital Centre São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto Portugal.

Address of Correspondence

Dr. Alina Frolova,
Department of Pediatric Orthopedics, The University Hospital Centre São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto Portugal.
E-mail: alina.frolova.238@gmail.com


Abstract

Pyomyositis is an uncommon clinical entity affecting predominantly pediatric population. It presents with diffuse muscle involvement, mostly in the lower limb, with occasional abscess formation and need of drainage, coupled to an appropriate antibiotic therapy.
In this article we present a case of a previously healthy 11-year old boy with an acute onset of hip pain and fever, as well as elevation in blood leukocyte count and C-reactive protein. Magnetic resonance imaging showed a gadolinium-enhanced oedema of internal obturator, external obturator, adductors and quadratus femoris, with an intra-muscular abscess of external obturator. After two attempted percutaneous drainages the patient progressed to sepsis, with the need of open surgical drainage through transgluteal approach. Concomitantly, a deep venous thrombosis was also diagnosed.
After the appropriate drainage and a prolonged antibiotic regimen, patient’s condition improved, with full recovery and no sequelae.
Keywords: Pyomyositis, External obturator, Muscle abscess, Transgluteal approach


References

1. Maravelas R, Melgar TA, Vos D, Lima N, Sadarangani S. Pyomyositis in the United States 2002-2014. J Infect. 2020 May;80(5):497-503
2. Bickels J, Ben-Sira L, Kessler A, Wientroub S. Primary pyomyositis. J Bone Joint Surg Am. 2002 Dec;84(12):2277-86
3. Moriarty P, Leung C, Walsh M, Nourse C. Increasing pyomyositis presentations among children in Queensland, Australia. Pediatr Infect Dis J. 2015 Jan;34(1):1-4
4. Moriuchi Y, Fuchigami T, Sugiyama C, Takahashi S, Ohashi Y, Yonezawa R, Mizukoshi W, Morioka I. Obturator pyomyositis and labium majus cellulitis: A case report and literature review. SAGE Open Med Case Rep. 2022 Mar 25
5. Kiran M, Mohamed S, Newton A, George H, Garg N, Bruce C. Pelvic pyomyositis in children: changing trends in occurrence and management. Int Orthop. 2018 May;42(5):1143-1147
6. García-Mata S, Hidalgo-Ovejero A, Esparza-Estaun J. Primary obturator-muscle pyomyositis in immunocompetent children. J Child Orthop. 2012 Jul;6(3):205-15
7. Ovadia D, Ezra E, Ben-Sira L, Kessler A, Bickels J, Keret D, Yaniv M, Wientroub S, Lokiec F. Primary pyomyositis in children: a retrospective analysis of 11 cases. J Pediatr Orthop B. 2007 Mar;16(2):153-9
8. Comegna L, Guidone PI, Prezioso G, Franchini S, Petrosino MI, Di Filippo P, Chiarelli F, Mohn A, Rossi N. Pyomyositis is not only a tropical pathology: a case series. J Med Case Rep. 2016 Dec 21;10(1):372
9. Unnikrishnan PN, Perry DC, George H, Bassi R, Bruce CE. Tropical primary pyomyositis in children of the UK: an emerging medical challenge. Int Orthop. 2010 Feb;34(1):109-13
10. Sánchez-Rodríguez HM, Morales-Ávalos R, Rivera-Zarazúa S, Ramírez-Elizondo MT, Hernández-Rodríguez PA, Vílchez-Cavazos F, Peña-Martínez VM. Piomiositis tropical del músculo ilíaco, obturador interno, piriforme y psoas mayor en un paciente inmunocompetente con claudicación [Tropical pyomyositis of the iliacus, obturator internus, piriformis and psoas major muscles in an immunocompetent patient with claudication]. Acta Ortop Mex. 2021 Jan-Feb;35(1):80-84. Spanish.
11. Tawfik D, Hobson WL. Group A Streptococcal Pyomyositis in a Previously Healthy Six-year-old Girl. Cureus. 2018 Feb 8;10(2):e2168
12. Menge TJ, Cole HA, Mignemi ME, Corn WC, Martus JE, Lovejoy SA, Stutz CM, Mencio GA, Schoenecker JG. Medial approach for drainage of the obturator musculature in children. J Pediatr Orthop. 2014 Apr-May;34(3):307-15
13. White S, Stopka S, Nimityongskul P, Jorgensen D. Transgluteal Approach for Drainage of Obturator Internus Abscess in Pediatric Patients. J Pediatr Orthop. 2017 Jan;37(1):e62-e66


How to Cite this Article:  Frolova A, Freitas J, Martins R, Coutinho J | A Case of Pyomyositis in a Healthy 11-Year Old Boy with Need of Surgical Drainage | International Journal of Paediatric Orthopaedics | January-April 2022; 8(1): 47-50.

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