License
International Journal of Paediatric Orthopaedics is licensed under a
https://creativecommons.org/licenses/by-nc-sa/4.0/
Publisher
Official Journal of:
Paediatric Orthopaedic Society of India (POSI)
Publisher:
ResearchOne Publishing House,
An "Indian Orthopaedic Research Group (IORG) initiative.
IORG House,
A-203, Manthan Apts, Shreesh CHS, Hajuri Road,
Thane [West], Maharashtra, India.
Pin Code- 400604
Tel- 02225834545
Publisher Email: indian.ortho@gmail.com
Editor Email: editor.ijpo@gmail.com
pwktoto
boom138
hk lotto
sibayak99
triadtoto
triadtoto
triad4d
boom138
triad4d
triadtoto
triad4d
spin338
holyslot123
Amanah99
Rupiah777
horastogel
cuanslot
okta138
tango168
lotus777
bostoto138
medali69
milojitu
Lotre78
lux77
Gorilatoto
Hoki338
Dewapoker77
baikbet
sule78
lavatoto
uang138
Merak99
porto4d
hemattoto
Kaca138
puri138
anginbet
Joglo4d
juragantogel
Mahyong69
sojubet
sakti777
StarJoker69
grab78
spacetogel
jarum169
Kudatoto
pangkalanbet
ten88
opera99
satelit69
koin88
pondok338
jaring338
pubtogel
milo338
thor388
deltatoto
bdjitu
mirana99
amat123
autobet123
Shio77
gemoy188
planet888
Maria99
makmurwin
pakdejp
geber777
lato777
Melatibet
bankslot
hujantogel
coco69
Rusa69
Apollo303
sule777
namabet
Mars77
moon138
Pancingslot
Pulaubet
rumah88
cumi303
prada68
versace138
Koala4d
lobby69
lux78
usaha4d
kambingtogel
Musangtoto
delta777
Jeweltoto
pos188
lava77
maluku303
kompor88
luckslot
Lotre169
lotus68
raffi169
tambang388
ratuzeusqq
dinasti99
Modalhoki108
asiajitu
judi78
astra78
partaiqq
rumah69
Meriam123
evosbet88
Sayangbet
Lilin4d
Cemaraslot
furla69
kumis4d
Bandungslot
japan78
hokislot123
hulk303
Pragmatic69
chivas69
krisna188
Lyonslot
ASIABET168
topislot
bola123
ultra365
ios55
kompor77
sinaga138
kelapabet
padang777
Rajawin777
Jakarta88slot
Becak168
babetogel
primaslot
Moonslot
palu338
pulautogel
botaktogel
platinum138
cici169
gunturtogel
Kacang4d
dewabet138
spin388
homebet69
bursatoto
mami4d
pasbet
aduhoki
lava69
pagoda388
meledak99
dalang138
Gama188
dino777
papua338
darat123
hokiwin55
Cobra777
Merak88
crown78
preman77
grab188
terminal388
apiwin
madura78
sinar303
Dupawin
Santuy188
kera388
Modalhoki68
omuslot
Peri123
divabet
macau388
Angsa138
keris69
DOMINOPKV
Bos69
Sawitjitu
jaring99
layar77
tayototo
taro168
pejuang388
next88
harapan168
hemat123
Shio88
apidewa77
parisjp
pohon69
Lotre777
taruna123
asean168
giga69
StarJoker123
tempat99
Sisir4d
Tokek78
bosstogel
pakdeslot88
wisslot
rumah108
dominoslot
cola123
jili88
kompas77
bisnis77
kungfu69
Arjuna77
sensa123
Piramida4d
gacor365
pucuk777
Lotre123
wayang777
Gama178
WLA88
langitmpo
Robot4d
kumbang123
Logam4d
Sawit138
Bca168
petir88
tokyobet
tempo123
Permen178
Gacorbos99
wiratogel
LUNAS805
sateslot
barbar188
maxwin123
pecahtogel
Menang77
demotogel
trisula4d
candy138
bostoto188
demo388
citatogel
SIRKUIT138
Boy4d
Kalaslot
formulabet
Kode99
icon55
domino123
cartel303
jingga4d
Luxuryqq
space168
Legenda4d
porto169
api69
ASIAMPO77
wiki69
fasslot
cincin77
rajatoto68
Merak78
batastogel
gem108
buku99
furlabet
versace168
Sayang777
marvel365
kumis138
sushitoto
cbototo
latar77
Hadiah4d
solusi138
udara4d
sayang188
maha777
milo55
taro303
Dunia88
sejuta188
Dewapokertogel
Luxurygg
KOBOYPOKER
Aksara77
amat303
unggul123
oris77
kingdomjitu
merci4d
Aontoto
gemoyslot
geloratoto
layar69
winning138
sobet78
klik303
gilagg
bantamtoto
Sbo4d
Tombol4d
maya303
spin6d
sumo123
lambe88
barbar88
kadobet168
solid169
oasis365
karo303
duta69
sumo88
Pandawa123
ipar777
bengkelslot
macanslot
abc69
judolbetqq
Laku123
obor77
Lampion4d
memori77
jepang169
plntoto
ASIAPKV
Duyung88
Hijau123
dewanslot
MAXWIN888
SUARABET77
empirebet
Kucingtoto
kakek138
idr188
coca123
sisri77
jamu123
cumi99
fire123
persentogel
moon4d
dutabet
jaring365
Bigwin178
Gacorbos169
toto388
evosgamingg
kado99
WLA55
kadal303
rumah168
Poker138
Aztectoto
gasing78
extrabet
urban168
Topengslot
planet388
Angkatoto77
mulia88
qq69
luck388
epictogel
GACORBOS
icon169
atlas169
bentototo
jamu4d
libas169
holiday69
hulk77
skor77
karo168
colekbet
Bendera99
suhu4d
Dayak123
radentogel
KOBOY888
memori108
lajubet888
JUARAWIN88
BIMO77
jokerbetqq
AREASLOTO
juara77
dewi138
DEWIBET777
nusapoker
jilibet
Ikan303
kadalslot
depototo
harum123
pawang88
krisna123
madu55
Khusustogel
taktik388
Wahana4d
ovo168
mesinslot
Gogo90
bromo99
Badutjitu
Mega777
sentosa69
kamus168
Tigerslot
tempatslot
wazebet
sekai777
airtogel
Agen99
colek777
pasang388
pigi388
Angkatoto123
batam69
kudetabet69
mewah123
fuji338
papua78
murahpoker
cincin365
memori69
hantu78
anak777
Kapten99
Nanas188
Glory77
wiki78
PEDANGBET
mahjongs138
ipar78
motoslot88
POV99
bingo4d
ratuslot777
YUPI188
ASIASLOT888
fire777
pasti138
batam777
julietslot
iklan88
kamus77
sobet99
capital99
Sicbo4d
paris4d
daya365
amat168
roslot55
Kaktusslot
cakra123
Abu123
krisna77
guntur365
PEDANGJITU
panca123
Kodok123
ASIAKING777
JPSLOT168
wuling88
kaya77
KOBOIBOLA
garpu777
kingbet169
pir69
extra188
oren77
cair365
kingdomjp
dewaslot138
nagapoker777
cici138
Daun777
surga6d
holyslottoto
jakarta303
dinasti777
suara78
Mbah4d
HOKIOM88
zona77
unggul169
tempat123
Arus138
retro388
mampirtoto
sulaptogel
nagawin168
pecah188
bangsa338
ASIAHOKI88
neopoker
mesin188
canduslot777
dino78
asus88
Mangga4d
kumistogel
nama88
kkslot55
LUNA999
Tokcer69
Logam303
kkslot108
lgo188
gemoy777
ultra99
tahunslot
ligajp88
kampusslot
babe69
macau128
taktik123
kado338
Angsa77
latarslot
juliet777
lavaslot
suburbet
doyan77
ladang77
Dupaslot
YUPIBET
AREA188
betagg
usaha169
AREAWIN88
megawinbet
Tokcer168
mandiri99
MANTAP138
mahal99
Gobertogel
abc77
mulia99
bonus303
kembar388
sensatogel
atom188
gebyar77
baik388
balon138
Master77
ovo338
gaco169
edanbet
pistolslot
air169
kembang169
dna303
wigo123
ladangslot
pasang338
suryatogel
DOMINOBET77
kembar188
diva388
pohonjitu
Sakuraqq
kumis168
ASIATOTO777
Premium188
rupiah4d
CERIAPOKER
KAYA78
kebunbet
sawi69
pub365
pesiar69
Wild777
Tores777
paus168
bom108
Dollarjitu
vegas77
wis338
Kancil69
angkasaslot
Dolan138
semangat303
jaritogel
daun69
nova123
darat303
SERUBET88
selat123
hantu88
serbatoto
balon123
tenbet
padi78
benuawin
Sensa188
Emas88
Rajawalitogel
musangtogel
sarana78
sugar365
lexus108
bom123
kso123
luck4d
puncak88
vista123
muara69
Rutantoto
ceria88
RAFI777
alasbet
durentoto
mpomaster
cipitbet
usaha138
leobet
mantra168
Akun188
Nanastogel
alexa88
Tombol168
slotbom68
solid78
gunturslot
sake138
Gloryslot
luck77
raksasa138
mildbet
Doku123
Yakuza777
bostoto77
jutawan168
odin123
lampu168
cumi168
mega169
puri188
petatogel
dadu168
mahadewa168
karirtogel
istana88
serbu123
kumbang99
pulau169
Sarangslot88
muliaslot
tiktoktoto
retro4d
ayo68
Dugem88
jepe338
bns99
leo303
turbo77
timur77
baiktogel
masterbet123
Mansionslot
petirslot
retro69
unggul168
POV69
musik168
kapaljudi777
Habanero138
marvel188
kejubet
ios99
Ninjaslot
permen169
fix338
koi138
madura168
gerbang338
desa77
sushi168
Ikanslot
opera123
oren365
luckbet
Rusa77
Ungu77
hugo99
medan123
zodiaktoto
papua168
mansion88
luck99
asean188
rajazeus138
seru78
kampung99
Target99
gas123
coca4d
dinastibet
sultanbet188
Alamtoto
pwktoto pwktoto
pwktoto
nagatoto
boom138
rajagaming-51
rajagaming-52
rajagaming-53
rajagaming-54
rajagaming-55
rajagaming-56
rajagaming-57
rajagaming-58
rajagaming-59
rajagaming-6
rajagaming-60
rajagaming-61
rajagaming-62
rajagaming-63
rajagaming-64
rajagaming-65
rajagaming-66
rajagaming-67
rajagaming-68
rajagaming-69
rajagaming-7
rajagaming-70
rajagaming-71
rajagaming-72
rajagaming-73
rajagaming-74
rajagaming-75
rajagaming-76
rajagaming-77
rajagaming-78
rajagaming-79
rajagaming-8
rajagaming-80
rajagaming-81
rajagaming-82
rajagaming-83
rajagaming-84
rajagaming-85
rajagaming-86
rajagaming-87
rajagaming-88
rajagaming-89
rajagaming-9
rajagaming-90
rajagaming-91
rajagaming-92
rajagaming-93
rajagaming-94
rajagaming-95
rajagaming-96
rajagaming-97
rajagaming-98
rajagaming-99
sibayak99
nagatoto88
triad4d
triadmacau
pwktoto
boom138
sibayak99
vinaslot
triadtotogroup
nagatoto88
garwa4d
Kirintoto
triadsgp
triadsyd
triadjitu
triadmacau
triadtoto
triadtogel
triad4d
triadhk
torpedo99
scatter99
boom138
bosslot138
sibayak99
emas69
triad303
triadslot
pwktoto
pwktoto
garwa4d
agamslot
agam138
nagatoto88
dewihoky
kudatoto
scatter99
emas69
superwinslot
lidoslot
lido123
lido69
kawal69
tvjp
triadhk
HK LOTTO
iconbet
jpspin88
jpspin303
mikrostar88
sontoto
suka777
triadtogel
torpedo4d
daget169
HK LOTTO
pwktoto
pwktoto
bentengslot
bentengtoto
benteng99
bintangjp88
kretektogel
bantengslot
gwktoto
waktoto
vinaslot
vinaslot
pwk777
triadhk
triadmacau
triadjitu
triadhk
garwa4d
torpedo4d
nagatoto88
sibayak99
triad4d
triadtogel
triad4d
torpedo4d
boom138
emas69
scatter99
pwktoto
boom138
pwktoto
nagatoto88
nagatoto88
boom138
triad4d
triadtogel
triadjitu
boom138
triadtoto
triadtogel
triadhk
nagatoto88
garwa4d
torpedo4d
triadmacau
triadtoto
triadmacau
triadtoto
triadtogel
triadhk
scatter99
sibayak99
emas69
triadjitu
emas69
scatter99
sibayak99
boom138
pwktoto
torpedo4d
torpedo4d
torpedo4d
torpedo4d
nagatoto88
nagatoto88
nagatoto88
garwa4d
garwa4d
garwa4d
triadtoto
triadtoto
triadtoto
triadtogel
triadtogel
triadtogel
triad4d
triad4d
triad4d
triad4d
triad4d
triad4d
triadhk
triadhk
triadhk
triadhk
triadhk
triadhk
triadmacau
triadmacau
triadjitu
triadjitu
triadjitu
scatter99
scatter99
scatter99
scatter99
scatter99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
boom138
emas69
emas69
rokettoto
rokettoto
rokettoto
rokettoto
bukitdita
kirintoto
kirintoto
triadsgp
triadsgp
triadsyd
triadsyd
torpedo99
torpedo99
torpedo99
torpedo99
premium138
premium138
premium138
premium138
premium138
premium138
bosslot138
bosslot138
bosslot
bosslot138
bosslot138
pusat69
pusat69
dompet69
dompet69
dompet69
dompet138
dompet188
dompet168
dompet123
harta69
triadslot
triadslot
triad303
138vip
138vip
triadtogel
triadtoto
triad4d
triadhk
pancawin
badaitoto
triadtoto
vinaslot
torpedo4d
pwktoto boom138
pwktoto
pwktoto
triadtoto
triadhk
triad4d
triadtogel
triadjitu
triadmacau
boom138
garwa4d
scatter99
emas69
torpedo4d
nagatoto88
vinaslot
vinaslot
vinaslot
pwktoto
bejo99
langit188
pwktoto
boom138
hk lotto
sibayak99
triadtoto
triadtoto
triad4d
boom138
triad4d
triadtoto
triad4d
spin338
holyslot123
Amanah99
Rupiah777
horastogel
cuanslot
okta138
tango168
lotus777
bostoto138
medali69
milojitu
Lotre78
lux77
Gorilatoto
Hoki338
Dewapoker77
baikbet
sule78
lavatoto
uang138
Merak99
porto4d
hemattoto
Kaca138
puri138
anginbet
Joglo4d
juragantogel
Mahyong69
sojubet
sakti777
StarJoker69
grab78
spacetogel
jarum169
Kudatoto
pangkalanbet
ten88
opera99
satelit69
koin88
pondok338
jaring338
pubtogel
milo338
thor388
deltatoto
bdjitu
mirana99
amat123
autobet123
Shio77
gemoy188
planet888
Maria99
makmurwin
pakdejp
geber777
lato777
Melatibet
bankslot
hujantogel
coco69
Rusa69
Apollo303
sule777
namabet
Mars77
moon138
Pancingslot
Pulaubet
rumah88
cumi303
prada68
versace138
Koala4d
lobby69
lux78
usaha4d
kambingtogel
Musangtoto
delta777
Jeweltoto
pos188
lava77
maluku303
kompor88
luckslot
Lotre169
lotus68
raffi169
tambang388
ratuzeusqq
dinasti99
Modalhoki108
asiajitu
judi78
astra78
partaiqq
rumah69
Meriam123
evosbet88
Sayangbet
Lilin4d
Cemaraslot
furla69
kumis4d
Bandungslot
japan78
hokislot123
hulk303
Pragmatic69
chivas69
krisna188
Lyonslot
ASIABET168
topislot
bola123
ultra365
ios55
kompor77
sinaga138
kelapabet
padang777
Rajawin777
Jakarta88slot
Becak168
babetogel
primaslot
Moonslot
palu338
pulautogel
botaktogel
platinum138
cici169
gunturtogel
Kacang4d
dewabet138
spin388
homebet69
bursatoto
mami4d
pasbet
aduhoki
lava69
pagoda388
meledak99
dalang138
Gama188
dino777
papua338
darat123
hokiwin55
Cobra777
Merak88
crown78
preman77
grab188
terminal388
apiwin
madura78
sinar303
Dupawin
Santuy188
kera388
Modalhoki68
omuslot
Peri123
divabet
macau388
Angsa138
keris69
DOMINOPKV
Bos69
Sawitjitu
jaring99
layar77
tayototo
taro168
pejuang388
next88
harapan168
hemat123
Shio88
apidewa77
parisjp
pohon69
Lotre777
taruna123
asean168
giga69
StarJoker123
tempat99
Sisir4d
Tokek78
bosstogel
pakdeslot88
wisslot
rumah108
dominoslot
cola123
jili88
kompas77
bisnis77
kungfu69
Arjuna77
sensa123
Piramida4d
gacor365
pucuk777
Lotre123
wayang777
Gama178
WLA88
langitmpo
Robot4d
kumbang123
Logam4d
Sawit138
Bca168
petir88
tokyobet
tempo123
Permen178
Gacorbos99
wiratogel
LUNAS805
sateslot
barbar188
maxwin123
pecahtogel
Menang77
demotogel
trisula4d
candy138
bostoto188
demo388
citatogel
SIRKUIT138
Boy4d
Kalaslot
formulabet
Kode99
icon55
domino123
cartel303
jingga4d
Luxuryqq
space168
Legenda4d
porto169
api69
ASIAMPO77
wiki69
fasslot
cincin77
rajatoto68
Merak78
batastogel
gem108
buku99
furlabet
versace168
Sayang777
marvel365
kumis138
sushitoto
cbototo
latar77
Hadiah4d
solusi138
udara4d
sayang188
maha777
milo55
taro303
Dunia88
sejuta188
Dewapokertogel
Luxurygg
KOBOYPOKER
Aksara77
amat303
unggul123
oris77
kingdomjitu
merci4d
Aontoto
gemoyslot
geloratoto
layar69
winning138
sobet78
klik303
gilagg
bantamtoto
Sbo4d
Tombol4d
maya303
spin6d
sumo123
lambe88
barbar88
kadobet168
solid169
oasis365
karo303
duta69
sumo88
Pandawa123
ipar777
bengkelslot
macanslot
abc69
judolbetqq
Laku123
obor77
Lampion4d
memori77
jepang169
plntoto
ASIAPKV
Duyung88
Hijau123
dewanslot
MAXWIN888
SUARABET77
empirebet
Kucingtoto
kakek138
idr188
coca123
sisri77
jamu123
cumi99
fire123
persentogel
moon4d
dutabet
jaring365
Bigwin178
Gacorbos169
toto388
evosgamingg
kado99
WLA55
kadal303
rumah168
Poker138
Aztectoto
gasing78
extrabet
urban168
Topengslot
planet388
Angkatoto77
mulia88
qq69
luck388
epictogel
GACORBOS
icon169
atlas169
bentototo
jamu4d
libas169
holiday69
hulk77
skor77
karo168
colekbet
Bendera99
suhu4d
Dayak123
radentogel
KOBOY888
memori108
lajubet888
JUARAWIN88
BIMO77
jokerbetqq
AREASLOTO
juara77
dewi138
DEWIBET777
nusapoker
jilibet
Ikan303
kadalslot
depototo
harum123
pawang88
krisna123
madu55
Khusustogel
taktik388
Wahana4d
ovo168
mesinslot
Gogo90
bromo99
Badutjitu
Mega777
sentosa69
kamus168
Tigerslot
tempatslot
wazebet
sekai777
airtogel
Agen99
colek777
pasang388
pigi388
Angkatoto123
batam69
kudetabet69
mewah123
fuji338
papua78
murahpoker
cincin365
memori69
hantu78
anak777
Kapten99
Nanas188
Glory77
wiki78
PEDANGBET
mahjongs138
ipar78
motoslot88
POV99
bingo4d
ratuslot777
YUPI188
ASIASLOT888
fire777
pasti138
batam777
julietslot
iklan88
kamus77
sobet99
capital99
Sicbo4d
paris4d
daya365
amat168
roslot55
Kaktusslot
cakra123
Abu123
krisna77
guntur365
PEDANGJITU
panca123
Kodok123
ASIAKING777
JPSLOT168
wuling88
kaya77
KOBOIBOLA
garpu777
kingbet169
pir69
extra188
oren77
cair365
kingdomjp
dewaslot138
nagapoker777
cici138
Daun777
surga6d
holyslottoto
jakarta303
dinasti777
suara78
Mbah4d
HOKIOM88
zona77
unggul169
tempat123
Arus138
retro388
mampirtoto
sulaptogel
nagawin168
pecah188
bangsa338
ASIAHOKI88
neopoker
mesin188
canduslot777
dino78
asus88
Mangga4d
kumistogel
nama88
kkslot55
LUNA999
Tokcer69
Logam303
kkslot108
lgo188
gemoy777
ultra99
tahunslot
ligajp88
kampusslot
babe69
macau128
taktik123
kado338
Angsa77
latarslot
juliet777
lavaslot
suburbet
doyan77
ladang77
Dupaslot
YUPIBET
AREA188
betagg
usaha169
AREAWIN88
megawinbet
Tokcer168
mandiri99
MANTAP138
mahal99
Gobertogel
abc77
mulia99
bonus303
kembar388
sensatogel
atom188
gebyar77
baik388
balon138
Master77
ovo338
gaco169
edanbet
pistolslot
air169
kembang169
dna303
wigo123
ladangslot
pasang338
suryatogel
DOMINOBET77
kembar188
diva388
pohonjitu
Sakuraqq
kumis168
ASIATOTO777
Premium188
rupiah4d
CERIAPOKER
KAYA78
kebunbet
sawi69
pub365
pesiar69
Wild777
Tores777
paus168
bom108
Dollarjitu
vegas77
wis338
Kancil69
angkasaslot
Dolan138
semangat303
jaritogel
daun69
nova123
darat303
SERUBET88
selat123
hantu88
serbatoto
balon123
tenbet
padi78
benuawin
Sensa188
Emas88
Rajawalitogel
musangtogel
sarana78
sugar365
lexus108
bom123
kso123
luck4d
puncak88
vista123
muara69
Rutantoto
ceria88
RAFI777
alasbet
durentoto
mpomaster
cipitbet
usaha138
leobet
mantra168
Akun188
Nanastogel
alexa88
Tombol168
slotbom68
solid78
gunturslot
sake138
Gloryslot
luck77
raksasa138
mildbet
Doku123
Yakuza777
bostoto77
jutawan168
odin123
lampu168
cumi168
mega169
puri188
petatogel
dadu168
mahadewa168
karirtogel
istana88
serbu123
kumbang99
pulau169
Sarangslot88
muliaslot
tiktoktoto
retro4d
ayo68
Dugem88
jepe338
bns99
leo303
turbo77
timur77
baiktogel
masterbet123
Mansionslot
petirslot
retro69
unggul168
POV69
musik168
kapaljudi777
Habanero138
marvel188
kejubet
ios99
Ninjaslot
permen169
fix338
koi138
madura168
gerbang338
desa77
sushi168
Ikanslot
opera123
oren365
luckbet
Rusa77
Ungu77
hugo99
medan123
zodiaktoto
papua168
mansion88
luck99
asean188
rajazeus138
seru78
kampung99
Target99
gas123
coca4d
dinastibet
sultanbet188
Alamtoto
pwktoto pwktoto
pwktoto
nagatoto
boom138
rajagaming-51
rajagaming-52
rajagaming-53
rajagaming-54
rajagaming-55
rajagaming-56
rajagaming-57
rajagaming-58
rajagaming-59
rajagaming-6
rajagaming-60
rajagaming-61
rajagaming-62
rajagaming-63
rajagaming-64
rajagaming-65
rajagaming-66
rajagaming-67
rajagaming-68
rajagaming-69
rajagaming-7
rajagaming-70
rajagaming-71
rajagaming-72
rajagaming-73
rajagaming-74
rajagaming-75
rajagaming-76
rajagaming-77
rajagaming-78
rajagaming-79
rajagaming-8
rajagaming-80
rajagaming-81
rajagaming-82
rajagaming-83
rajagaming-84
rajagaming-85
rajagaming-86
rajagaming-87
rajagaming-88
rajagaming-89
rajagaming-9
rajagaming-90
rajagaming-91
rajagaming-92
rajagaming-93
rajagaming-94
rajagaming-95
rajagaming-96
rajagaming-97
rajagaming-98
rajagaming-99
sibayak99
nagatoto88
triad4d
triadmacau
pwktoto
boom138
sibayak99
vinaslot
triadtotogroup
nagatoto88
garwa4d
Kirintoto
triadsgp
triadsyd
triadjitu
triadmacau
triadtoto
triadtogel
triad4d
triadhk
torpedo99
scatter99
boom138
bosslot138
sibayak99
emas69
triad303
triadslot
pwktoto
pwktoto
garwa4d
agamslot
agam138
nagatoto88
dewihoky
kudatoto
scatter99
emas69
superwinslot
lidoslot
lido123
lido69
kawal69
tvjp
triadhk
HK LOTTO
iconbet
jpspin88
jpspin303
mikrostar88
sontoto
suka777
triadtogel
torpedo4d
daget169
HK LOTTO
pwktoto
pwktoto
bentengslot
bentengtoto
benteng99
bintangjp88
kretektogel
bantengslot
gwktoto
waktoto
vinaslot
vinaslot
pwk777
triadhk
triadmacau
triadjitu
triadhk
garwa4d
torpedo4d
nagatoto88
sibayak99
triad4d
triadtogel
triad4d
torpedo4d
boom138
emas69
scatter99
pwktoto
boom138
pwktoto
nagatoto88
nagatoto88
boom138
triad4d
triadtogel
triadjitu
boom138
triadtoto
triadtogel
triadhk
nagatoto88
garwa4d
torpedo4d
triadmacau
triadtoto
triadmacau
triadtoto
triadtogel
triadhk
scatter99
sibayak99
emas69
triadjitu
emas69
scatter99
sibayak99
boom138
pwktoto
torpedo4d
torpedo4d
torpedo4d
torpedo4d
nagatoto88
nagatoto88
nagatoto88
garwa4d
garwa4d
garwa4d
triadtoto
triadtoto
triadtoto
triadtogel
triadtogel
triadtogel
triad4d
triad4d
triad4d
triad4d
triad4d
triad4d
triadhk
triadhk
triadhk
triadhk
triadhk
triadhk
triadmacau
triadmacau
triadjitu
triadjitu
triadjitu
scatter99
scatter99
scatter99
scatter99
scatter99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
sibayak99
boom138
emas69
emas69
rokettoto
rokettoto
rokettoto
rokettoto
bukitdita
kirintoto
kirintoto
triadsgp
triadsgp
triadsyd
triadsyd
torpedo99
torpedo99
torpedo99
torpedo99
premium138
premium138
premium138
premium138
premium138
premium138
bosslot138
bosslot138
bosslot
bosslot138
bosslot138
pusat69
pusat69
dompet69
dompet69
dompet69
dompet138
dompet188
dompet168
dompet123
harta69
triadslot
triadslot
triad303
138vip
138vip
triadtogel
triadtoto
triad4d
triadhk
pancawin
badaitoto
triadtoto
vinaslot
torpedo4d
pwktoto boom138
pwktoto
pwktoto
triadtoto
triadhk
triad4d
triadtogel
triadjitu
triadmacau
boom138
garwa4d
scatter99
emas69
torpedo4d
nagatoto88
vinaslot
vinaslot
vinaslot
pwktoto
bejo99
langit188
pwktoto


Osteochondroma Arising from the Head of the Fibula: A Rare Cause of Drop Foot in Pediatric Age
Volume 3 | Issue 1 | Jan-Jun 2017 | Page 2-5 | Pérez-Ortiz Sergio, Blas-Dobón JA, Peralta-Nieto J, Gómez-Barbero P
Authors : Pérez-Ortiz Sergio [1], Blas-Dobón JA [1], Peralta-Nieto J [1], Gómez-Barbero P [1].
[1] Hospital Universitario Doctor Peset, Valencia, Spain
Address of Correspondence
Dr. Sergio Perez Ortiz
Hospital Universitario Doctor Peset, Valencia, Spain.
Email: serperort@gmail.com
Abstract
Background: The common peroneal nerve (CPN) or external popliteal nerve is the most frequently involved nerve in entrapment syndromes in the lower extremities. Its proximity to the head of the fibula makes it particularly susceptible to damage by different injury mechanisms. Osteochondromas arising from the proximal fibula are a rare cause of common peroneal nerve injury.
Methods: We report a case of a 13-year-old Caucasian male patient referred to our hospital with drop foot and palpable mass in the head of the right fibula. Physical examination revealed a severe paresis, grade 2 objectified by the scale of the Medical Research Council (MRC) in the extensor hallucislongus, extensor digitorumlongus and tibialis anterior muscles and hypoesthesia in the dorsal surface of foot and portions of the anterior, lower-lateral leg. In magnetic resonance imaging (MRI) a tumor in the head of the fibula compressing the CPN is observed. Electromyographic studies confirmed the presence of severe partial axonotmesis of the right peroneal nerve.
The patient underwent surgery for decompression of the peroneal nerve and resection of the proximal fibula osteocartilaginousexostosis. The histopathological analysis confirmed the diagnosis of osteochondroma.
Results: At the 12-month postoperative follow-up the patient recovered sensitivity and presented, according to the MRC scale, muscle strength of 4 out of 5 in thepreviouslynamed muscles, being able to walk without orthotic devices. In the electromyography, subacuteaxonotmesis with important signs of active reinnervation observed
Conclusions : Osteochondroma in the head of the fibula is a rare cause of CPN injury, that can go easily unnoticed and has to be considered in the differential diagnosis of the drop foot in pediatric ages. Diagnosis and treatment should not be delayed to get a good neurological recovery because, otherwise, it could be irreversible.
Keywords: Drop foot, peroneal palsy, osteochondroma, tumor, nerve injury, surgery, nerve decompression, tumor of the fibula, pediatrics.
References
1. Çinar A, Yumrukçal F, Salduz A, Dirik Y, Eralp L. A rare cause of ‘drop foot’ in the pediatric age group: Proximal fibular osteochondroma a report of 5 cases. Int J Surg Case Rep 2014;5(12):1068-1071.
2. Dowson D. Entrapment Neuropathies. 2nd ed. Boston: Boston 7 Little, Brown and Company; 1990.
3. Flores LP, Koerbel A, Tatagiba M. Personal nerve compression resulting from fibular head osteophyte-like lesions. SurgNeurol 2005;64(3):249-252.
4. Mumenthaler M, Schliack H. Peripheral Nerves Lesions – Diagnosis and Therapy. New York: Stuttgart 7 Thieme Medical; 1991.
5. Abdel MP, Papagelopoulos PJ, Morrey ME, Wenger DE, Rose PS, Sim FH. Surgical management of 121 benign proximal fibula tumors. ClinOrthopRelat Res 2010;468(11):3056-3062.
6. Unni K. Dahlin’s Bone Tumors: General Aspects and Data on 11,087 Cases. Philadelphia, PA: Lippincot – Raven Publishers; 1996.
7. Kumar M, Malgonde M, Jain P. Osteochondroma arising from the proximal fibula: A rare presentation. J ClinDiagn Res 2014;8(4):LD01-LD03.
8. Flanigan RM, DiGiovanni BF. Peripheral nerve entrapments of the lower leg, ankle, and foot. Foot Ankle Clin 2011;16(2):255-274.
9. Paternostro-Sluga T, Grim-Stieger M, Posch M, Schuhfried O, Vacariu G, Mittermaier C, et al. Reliability and validity of the Medical Research Council (MRC) scale and a modified scale for testing muscle strength in patients with radial palsy. J Rehabil Med 2008;40(8):665-671.
10. Yildiz C, Erler K, Atesalp AS, Basbozkurt M. Benign bone tumors in children. CurrOpinPediatr 2003;15(1):58-67.
11. Springfield DS, Gebhardt MC. Bone and soft tissue tumors. In: Morrissy RT, Weisnstein SL, editors. Lowell and Winter’s Pediatric Orthopedics. Philadelphia, PA: Lippincott Williams and Wilkins; 2001. p. 507-561.
12. Saglik Y, Altay M, Unal VS, Basarir K, Yildiz Y. Manifestations and management of osteochondromas: A retrospective analysis of 382 patients. ActaOrthopBelg 2006;72(6):748-755.
13. Bovée JV. Multiple osteochondromas. Orphanet J Rare Dis 2008;3(1):1-7.
14. Biermann JS. Common benign lesions of bone in children and adolescents. J PediatrOrthop 2002;22(2):268-273.
15. Kushner BH, Roberts SS, Friedman DN, Kuk D, Ostrovnaya I, Modak S, et al.Osteochondroma in long-term survivors of high-risk neuroblastoma. Cancer 2015;121(12):2090-2096.
16. Marcovici PA, Berdon WE, Liebling MS. Osteochondromas and growth retardation secondary to externally or internally administered radiation in childhood. PediatrRadiol 2007;37(3):301-304.
17. Unger EC, Gilula LA, Kyriakos M. Case report 430: Ischemic necrosis of osteochondroma of tibia. Skeletal Radiol 1987;16(5):416-421.
18. Khosla A, Parry RL. Costalosteochondroma causing pneumothorax in an adolescent: A case report and review of the literature. J PediatrSurg 2010;45(11):2250-2253.
19. Ferriter P, Hirschy J, Kesseler H, Scott WN. Popliteal pseudo aneurysm. A case report. J Bone Joint Surg Am 1983;65(5):695-697.
20. Van den Bergh FR, Vanhoenacker FM, De Smet E, Huysse W, Verstraete KL. Peroneal nerve: Normal anatomy and pathologic findings on routine MRI of the knee. Insights Imaging 2013;4(3):287-299.
21. Paprottka FJ, Machens HG, Lohmeyer JA. Partially irreversible paresis of the deep personal nerve caused by osteocartilaginous exocytosis of the fibula without affecting the tibia is anterior muscle. J PlastReconstrAesthetSurg 2012;65(8):e223-e225.
22. Bunch K, Hope E. An uncommon case of bilateral personal nerve palsy following delivery: A case report and review of the literature. Case Rep ObstetGynecol2014;2014:746480.
23. Mnif H, Koubaa M, Zrig M, Zammel N, Abid A. Personal nerve palsy resulting from fibular head osteochondroma. Orthopedics 2009;32(7):528.
24. Baima J, Krivickas L. Evaluation and treatment of personal neuropathy. Curr Rev Musculoskelet Med 2008;1(2):147-153.
25. Sunderland S, Bradley KC. The cross-sectional area of peripheral nerve trunks devoted to nerve fibers. Brain 1949;72(3):428-449.
26. Cardelia JM, Dormans JP, Drummond DS, Davidson RS, Duhaime C, Sutton L. Proximal fibular osteochondroma with associated personal nerve palsy: A review of six cases. J PediatrOrthop 1995;15(5):574-577.
27. Paik NJ, Han TR, Lim SJ. Multiple peripheral nerve compressions related to malignantly transform hereditary multiple exocytosis. Muscle Nerve 2000;23(8):1290-1294.
28. Bernard SA, Murphey MD, Flemming DJ, Kransdorf MJ. Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging. Radiology 2010;255(3):857-865.
29. Ozden R, Uruc V, Kalaci A, Dogramaci Y. Compression of common personal nerve caused by an extra neural ganglion cyst mimicking intermittent claudication. J Brachial PlexPeripher Nerve Inj 2013;8(1):5.
30. Pedrini E, Jennes I, Tremosini M, Milanesi A, Mordenti M, Parra A, et al. Genotype-phenotype correlation study in 529 patients with multiple hereditary exocytosis: Identification of “protective” and “risk” factors. J Bone Joint Surg Am 2011;93(24):2294-2302.
31. Chin KR, Kharrazi FD, Miller BS, Mankin HJ, Gebhardt MC. Osteochondromas of the distal aspect of the tibia or fibula. Natural history and treatment. J Bone Joint Surg Am 2000;82(9):1269-1278.
32. Pigott TJ, Jefferson D. Idiopathic common personal nerve palsy – A review of thirteen cases. Br J Neurosurg 1991;5(1):7-11.
(Abstract) (Full Text HTML) (Download PDF)
Correlation of Pirani Score and Ultrasound in Assessing the Severity of Clubfoot in Neonates Treated by Ponseti Method
Volume 3 | Issue 1 | Jan-Jun 2017 | Page 16-19 | Vineet Bajaj, Rahul Anshuman, Nikhil Verma, Mahipal Singh, Anupama Tandon, Neerav Anand Singh
Authors : Vineet Bajaj [1], Rahul Anshuman [1], Nikhil Verma [1], Mahipal Singh [1], Anupama Tandon [1], Neerav Anand Singh [1].
[1] Department of Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi-110095, India.
Address of Correspondence
Dr Rahul Anshuman
Department of Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi-110095, India.
Email: anshuman.cool@gmail.com
Abstract
Aim: The aim of this study is to correlate Pirani score and ultrasound in assessing the severity of clubfoot in neonates treated by Ponseti method.
Materials and Methods: A total of 32 ft with idiopathic congenital talipes equinovarus deformity in neonates were prospectively treated by Ponseti method. Pirani score and ultrasound parameters were measured 3 times, i.e., at the time of initial presentation, at 4 weeks of treatment, and at completion of treatment. Feet were divided according to Pirani score in groups: One (0–2.0), two (2.5–4), and three (4.5–6). Correlation between ultrasound parameters and Pirani score was evaluated using one-way ANOVA and Tukey test.
Results: Correlation between Pirani score and ultrasound parameters was statistically significant (p<0.05).
Conclusion: Ultrasound has the potential to accurately depict the pathoanatomy in clubfoot. Ultrasound is objective method to assess the severity of clubfoot. Pirani score and ultrasound correlated in severity of deformity and correction achieved along the course of treatment.
Keywords: Idiopathic congenital talipes equinovarus, Pirani score, Ponseti method, ultrasound.
References
1. Brewster MB, Gupta M, Pattison GT, Dunn-van der Ploeg ID. Ponseti casting: A new soft option. J Bone Joint Surg Br 2008;90:1512-5.
2. Matuszewski L, Gil L, Karski J. Early results of treatment for congenital clubfoot using the Ponseti method. Eur J Orthop Surg Traumatol 2012;22:403-6.
3. Porecha MM, Parmar DS, Chavda HR. Mid-term results of Ponseti method for the treatment of congenital idiopathic clubfoot–(a study of 67 clubfeet with mean five year follow-up). J Orthop Surg Res 2011;6:3.
4. Ponseti IV, Smoley EN. Congenital club foot: The results of treatment. J Bone Joint Surg Am 1963;45:2261-75.
5. Ponseti IV. Clubfoot management. J Pediatr Orthop 2000;20:699-700.
6. Bhargava SK, Tandon A, Prakash M, Arora SS, Bhatt S, Bhargava S. Radiography and sonography of clubfoot: A comparative study. Indian J Orthop 2012;46:229-35.
7. Wainwright AM, Auld T, Benson MK, Theologis TN. The classification of congenital talipes equinovarus. J Bone Joint Surg Br 2002;84:1020-4.
8. Shaheen S, Jaibala H, Pirani S. Intraobserver reliability in Pirani clubfoot severity scoring between a paediatric orthopedic surgeon and a physiotherapy assistant. J Pediatr Orthop B 2012;21:366-8.
9. Desai S, Aroojis A, Mehta R. Ultrasound evaluation of clubfoot correction during Ponseti treatment: A preliminary report. J Pediatr Orthop 2008;28:53-9.
10. El-Adwar KL, Taha Kotb H. The role of ultrasound in clubfoot treatment: Correlation with the Pirani score and assessment of the Ponseti method. Clin Orthop Relat Res 2010;468:2495-506.
11. Shiels WE 2nd, Coley BD, Kean J, Adler BH. Focused dynamic sonographic examination of the congenital clubfoot. Pediatr Radiol 2007;37:1118-24.
12. Gigante C, Talenti E, Turra S. Sonographic assessment of clubfoot. J Clin Ultrasound 2004;32:235-42.
13. Aurell Y, Johansson A, Hansson G, Wallander H, Jonsson K. Ultrasound anatomy in the normal neonatal and infant foot: An anatomic introduction to ultrasound assessment of foot deformities. Eur Radiol 2002;12:2306-12.
(Abstract) (Full Text HTML) (Download PDF)
Dr Ashok Johari – A Unique Journey of a Paediatric Orthopaedic Surgeon- Part I
Volume 2 | Issue 2 | May-Aug 2016 | Page 2-7| Ashok N. Johari
Authors :Ashok N. Johari [1]
[1] Director of The Enable International Center for Paediatric Musculoskeletal Care, India.
Address of Correspondence
Dr Ashok N Johari
Email ID: drashokjohari@hotmail.com
The Price of Greatness is Responsibility
– Winston Churchill –
Are you ready to add some excitement to your day? Look no further than the thrilling world of Plinko! Now, you can experience all the fun and excitement of this classic game from the comfort of your own home. Get ready to dive into the action and see if you have what it takes to come out on top!
What is Plinko?
Plinko is a classic game that has been entertaining audiences for decades. It originated as a popular segment on the hit game show “The Price Is Right” and has since become a beloved pastime for people of all ages. The game involves dropping a ball down a pegged board, watching as it bounces off obstacles and lands in slots with varying prize values.
How to Play Plinko Online
Play plinko online is easy and convenient. Here’s a quick rundown of how to get started:
Find a Reputable Online Casino: Start by finding a reputable online casino that offers Plinko as one of its games. Look for a site with positive reviews and a user-friendly interface.
Navigate to the Plinko Game: Once you’ve found a suitable online casino, navigate to the section that features Plinko. You may need to create an account and make a deposit before you can start playing.
Place Your Bet: Before you can begin playing, you’ll need to place your bet. Choose your desired stake and select where you want to drop the ball.
Drop the Ball: Once your bet is placed, it’s time to drop the ball and watch as it makes its descent down the Plinko board. Will you land on a high-value slot and win big, or will you walk away empty-handed?
Collect Your Winnings: Depending on where the ball lands, you’ll either celebrate a big win or try your luck again. With each round of Plinko, there’s the chance for excitement and anticipation!
The Thrill of Playing Plinko Online
Playing Plinko online offers all the excitement of the traditional game, with the added convenience of being able to play from anywhere with an internet connection. Whether you’re at home, on the go, or even waiting in line, you can enjoy the thrill of dropping the ball and watching as it bounces its way to victory.
Why Play Plinko Online?
There are plenty of reasons to give Plinko a try online:
Convenience: With online Plinko, you can play whenever and wherever you want, without having to wait for a TV game show to come on.
Variety: Many online casinos offer different variations of Plinko, allowing you to choose the version that suits your preferences best.
Potential Winnings: Just like the game show version, online Plinko offers the chance to win real money prizes, adding an extra layer of excitement to the gameplay.
Play Plinko Online: Your Ticket to Fun and Excitement!
Ready to experience the thrill of Plinko for yourself? Head to your favorite online casino and start playing today! With its easy-to-understand gameplay and the potential for big wins, Plinko is sure to become one of your favorite online games in no time.
So why wait? Play Plinko online and see if you have what it takes to come out on top!
This interview with Dr Ashok Johari (ANJ) was conducted in Hotel Le Meredian. The interview was conducted by Dr Sandeep Patwardhan (SP) and Dr Ashok Shyam (AKS) on the second day of Pune Orthopaedic Society Annual Meeting in Pune, India.
The purpose of this interview is to know more about the journey of Dr Ashok Johari who is a pioneer in paediatric orthopaedics in India and in the world. This interview aims to catch a glimpse of his life and times and also showcase the rise of paediatric orthopaedic as an independent faculty in India. A broader objective is to attract people to paediatric orthopaedics and to have pride in our own people who have done exceptionally well in reaching international acclaim in respective fields.
AKS: Let me begin by asking you about your family background. Tell us something about your family and where you grew up?
ANJ: My father, Dr. N.K. Johari was an anaesthetist and my mother was a house wife. I was the only son among four daughters. One of the big aims of my father’s life was that we should be very well educated. He was a disciplined person himself and was particular about our studies and felt that we should do well in our exams. Not necessarily get first rank, but should get good education. He also focussed a lot on our extracurricular activities. One routine which is very interesting, which I would like to share. I had school weekly off on Thursday and my father insisted that I be with him on that day. He would go to different hospitals and take me with him to operation theatres (OT). He would want me to simply watch what is happening. I have these memories right from my age of five when I would stand on stools and watch surgeries in operation theatres from morning to evening. If on Thursday he didn’t have OT, he made sure that I was involved in some or the other work like washing the car, servicing the scooter etc. Everything had to be cleaned in the cars, carburettors had to be removed and cleaned. This helped me learn discipline from an early age.
My family was of medium means, though two generation ago we were quite rich. Our family were Jagirdars from Bikaner in Rajasthan. Once the Jagirdari went away, we were jewellers to all the princes of Rajasthan and South India. However somewhere things went wrong and by the time my father was young, most of the wealth had disappeared and my father had to work very hard. So I always had great respect and appreciation for him. He came to Mumbai for medical education and then stayed back here.
I was a sickly child specially bronchitis. Sometimes I used to get status asthamaticus and my father used to give me deriphylline drips, oxygen, everything at home. This also brought me in contact with doctors other than my father and that is the time I decided to become a doctor.
AKS: In fact our next question is on the topic of how did you decide to become a doctor, how did you get the inspiration?
ANJ: My father was my first inspiration. Vising OT’s and watching surgeries over the years developed interest and then being a ‘sick’ child I came into contact with many other doctors. These are the factors that influenced my decision to become a doctor. My father was not very keen on me becoming a doctor. Although he would take me around for cases, but he realised that the profession was degrading in someways and he did not want me to join medicine. I had to literally fight with him to enter medical college. In fact I said that if he did not want to pay the fees, I would raise money but I would definitely go to medical college.
I was in a technical school and from very early in life I had resolved to become a doctor specially influenced by watching surgeons in OT. These surgeons were associated with a lot of ‘Drama’ and glamour which really attracted me. After my 7th standard I had to opt out from normal school to go to a technical school. In our school we had this system of cumulative record. Our whole academic records were entered and we were asked our ambitions in life. Everywhere in my cumulative record my ambition is written as ‘I want to become a doctor and specifically orthopaedic surgeon’, right from my 8th standard. I topped the school and went to Jai Hind College and then entered medical college.
SP: Which medical school did you go for your MBBS.
ANJ: I went to Grant Medical College (GMC), JJ Hospital, Mumbai. I had a sort of connection with GMC from childhood. My father was a honorary professor at GMC and I had frequented the college since a very young age. I liked the campus very much specially the old building. My father was a medical student at GMC in 1940’s. He had clicked tons of photographs of the GMC campus, college buildings and old buildings from that era. We displayed these in an exhibition in 1976 organised by me in GMC called EXPO -76. I used to be the Magazine Editor then. I used to see these pictures in my younger days and had decided that I would go to GMC. So I did my medical school at GMC.
At a paediatric orthopaedic course in England in April 1988. Some who can be identified are Dr. Gopalakrishnan of Chennai, Dr. Pachore now at Ahmedabad and at the extreme end is Dr.Rajveer Chinoy of Mumbai. Dr. Johari is to his right. Mr. Thomas and Mr. Baker are to Dr. Johari’s right
AKS: During medical school were there any influences that helped or formed your career? Why did you choose orthopaedic surgery?
ANJ: As you know I had already decided on orthopaedics long back, especially the drama and the glamour of orthopaedic surgeons attracted me strongly. While in third year of my medical school, when I was scheduled for the orthopaedic posting, Dr Joshipura was our head of department (HOD). On the first day he asked, ‘Who wants to become an orthopaedic surgeon’, and rather naively I raised my hand (laughs). From that day, I had a bullseye marked on my back and was targeted for everything. Dr Joshipura would ask me questions on anatomy, pathology and orthopaedics all the time and would comment ‘You want to be an orthopaedic surgeon and you don’t even know this!’ I realised that it was with a good intention but I really felt pressurised to the extent of mental agony (laughs again). Suddenly something happened and in the middle of my orthopaedic term, Dr Joshipura disappeared. Later we came to know that he had a tussle with the dean. The dean wanted him to come to his office to see a patient and he said that he was on rounds and insisted that the patient be sent to him to be seen after the rounds. On this point there was some argument and he resigned from the college.
1989, Orthopaedic Unit at JJ Hospital. Dr. Johari is sitting on the left with his teachers, Dr. J.C. Taraporvala (centre) and Dr. P.D. Hakim (right). Behind them are the 3 registrars – on the right Randip Bindra, centre Dr. Gautam Chakraborty and on his right Dr. Sanjay Mehta. All 3 registrars settled outside India
JJ Orthopaedics in the mid 1990’s- sitting on the left, Dr. Shakir Kapadia, Late Dr. D.G. Dongaonkar, Dr. Johari and Dr. Sudhir Joshi. Standing extreme right is Dr. Sangeet Gawhale and standing second from left is the late Dr. Sanjay Jagtap. Dr. Dongaonkar was subsequently also the Dean and then Vice Chancellor of the Maharashtra University of Health Sciences.
AKS: So who would you say, once you started orthopaedics as a registrar, were your early influences?
ANJ: By the time I came back for my residency Dr Taraporewala was the chief of orthopaedic surgery at GMC. But we got a chance to see all the great surgeons including Dr Masalawala. Especially on Saturdays when we had these Saturday departmental conferences at GMC where all people connected to the institution would come. Dr Ugrankar, Dr Kawarana etc and all the unit chiefs along with HOD. This gave us lot of opportunity to interact with these people. Dr Masalawala was at that time very well recognised, he had been the past president of Indian Orthopaedic Association. He was pioneer in tuberculosis of spine and had the largest series of around 400 cases (this was in late 70’s). He published that in Indian Journal of Surgery. These Saturday interactions allowed us to connect with these giants of Orthopaedics in India and learn first-hand from them. I did two terms one in orthopaedic surgery and one in general surgery. For general surgery we always preferred to go to St. George’s Hospital to work under Dr Kumbhani. He was a general surgeon turned orthopaedic surgeon. He was appointed as a general surgeon but did only orthopaedic work. There we would learn general surgery from other surgeons in the unit and do orthopaedic work with Dr Kumbani. In general surgery we got training in abdominal surgeries, appendectomy, hernia repairs and other common procedures which was quite helpful in life even later. Along with that we had advantage to continue doing and learning orthopaedics with Dr Kumbhani.
AKS: You were pioneer in Paediatric Orthopaedics in India? Tell us something about the Story? – Why did you choose it?
ANJ: This is an interesting story and many incidents happened serendipitously for me to land up as a paediatric orthopaedic surgeon. After my two house posts, there was a six month wait for the registrar post and instead of waiting and going back to JJ Hospital, I decided to join the Children’s Orthopaedic Hospital (COH) at Haji Ali, Mumbai. At that time there was this unique personality there, ‘Dr.Perin K Mullaferoze’ who was the HOD at COH. She was an intimidating lady orthopaedic surgeon and was a battle scarred war veteran. She was a Lt. Colonel in the British army and had fought in World War II. She had seen action in Middle East and Unified India which extended till what are now Afghanistan, Pakistan and Bangladesh. She was an authoritarian lady and she was also the HOD of orthopaedics at JJ Hospital prior to Dr Masalawala. She was the second HOD of Orthopaedics in JJ, but she left JJ and concentrated completely on children’s Orthopaedics, specifically cerebral palsy. So in effect she was the first paediatric orthopaedic surgeon in the country but focussed on very limited diseases. She was around 70 years of age when I joined.
AKS: This was in which year Sir?
ANJ: This was in 1980 and I instantly liked working in paediatric orthopaedics. I was very fond of children and used to play with kids. At that time there were lot of polio cases who visited us at COH. Treating polio had a very rational approach – like if we did a particular intervention the outcomes would be as expected. The disease as well as the management could be all very well explained by biomechanics and anatomy. I very much liked this rational – logical approach. I worked there for 6 months as a registrar before I returned back to JJ. I had a very good learning experience with Dr Mullaferoze. She was very particular about certain things like applying plaster. For her, the plasters should be very comfortable to the patient and well padded. She was very good surgically, especially older surgeries of poliomyelitis, arthrodesis etc. By the time I went to COH, she was already in her 70’s and had stopped operating, but we requested her to come to OT and she demonstrated surgeries to us. So my time at COH actually build the resolve in me to pursue paediatric orthopaedics. Although it might be surprising that I had a bioengineering background and was very interested in biomechanics and joint mechanics. I had already done advanced work in tribology and joint replacement. I did summer workshop on tribology at the Harcourt Butler Technological Institute, Kanpur. UGC used to hold this workshop which I attended during 1979. Joint replacement was a good upcoming field but I felt it won’t give me the challenges and the variety which paediatric orthopaedic would give me. Also my aptitude was for paediatric orthopaedics. For example if you see even now, paediatric orthopaedicians are more academically oriented, more studious, and soft spoken. They take their own time to do things, they mix with people, and they mix with children. Ego problems are also not many among paediatric orthopaedic surgeons. To be with children you have to be like children and let go of your ego. So I believe I was much more inclined to be a paediatric orthopaedic surgeon than anything else.
AKS: Did the specialty of paediatric orthopaedics exist in those days in India?
ANJ: No the speciality did not exist in those days, it was all general orthopaedic surgeons who did the paediatric work. COH was specialised in paediatric orthopaedics, started basically to deal with polio. So with polio it started dealing with other children orthopaedic problems. With decline of polio, it started dealing with cerebral plasy (CP) too. It became the first centre in India to deal with CP and one of the foremost in the world. In 1961, Dr Mullaferoze went to USA to study cerebral palsy. There was this PL-480 scheme that funded her. It also funded the setting up of the cerebral palsy centre at COH in1963 by the Americans. So the speciality of paediatric orthopaedics did not really exists in those days, but there were people who did major work in paediatric orthopaedics. But this was not exclusive work and they continued to do adult orthopaedic work too. For example Dr MG Kini, was one of the senior most orthopaedic surgeon who did lot of paediatric work and had published papers on the same. Dr Mullaferoze and Dr Dholakia worked as assistants to Dr Kini at COH. Dr Kini was HOD at Chennai and after his retirement he was invited to be director at COH. He was one of the first qualified orthopaedic surgeons, first to have an orthopaedic degree in India. He went to Liverpool and did his MCH and came back to start practising orthopaedic surgery exclusively. In later years he did a lot of paediatric work but not exclusively.
SP: The Kini Memorial oration at WIROC is dedicated to him
ANJ: Yes correct. He worked in Bombay at COH and when he retired Dr Mullaferoze took over from him as the director. Dr Dholakia was visiting consultant at COH, until he became full time consultant at Bombay Hospital. So the speciality definitely did not exists in those days as we see it today, but I was determined to pursue it. I continued to look for opportunities in paediatric orthopaedics and luckily in 1984, I came across an advertisement in Indian Journal of Orthopaedics (IJO). The advertisement was about a fellowship in paediatric orthopaedics in Japan. Fellowships were unheard of in those days and it was very difficult to get one. I only knew a fellowship in hand surgery in Singapore and a spine fellowships in Hong Kong. Prof. Marwah was HOD of Orthopaedics and Dean at Nagpur GMC and had connections with surgeons in Japan. He was also the President of Indian Orthopaedic Association at that time. A famous Japanese children’s hospital offered a fellowship to Dr Marwah, to send a young person for training to Japan and Dr Marwah placed an advertisement in IJO, which I came across, fortunately! I responded to the fellowship and sent him my CV and by good luck I was selected from a number of applicants. I got a call from Dr Marwah to be ready to go to Japan. Going to Japan was not going to be easy, as I understood that Japanese do not speak English and it was clear to me that I had to learn Japanese. I came to know about the confirmation for fellowship around 9 months before I had to actually leave. I utilised this time to learn Japanese and when I reached Japan, I did an intensive course in Japanese language. This enabled me to converse in Japanese. Writing Japanese was very difficult and takes years to learn but I learnt enough to at least converse with surgeons and patients. I was a lecturer at Sion hospital at that time. I finished my MS in 1981 from JJ and in 1982 I finished my registrarship. In 1982 I got the opportunity to be a tutor at Sion hospital. I was then lecturer at Sion where I would do trauma, spine, paediatric and also arthroscopy. Surprisingly I did lot of arthroscopy at that time. It was I, who actually discovered that Sion hospital has an arthroscope which no public hospital had! I was fooling with our OT sister and rummaging through her cupboard when I found a Karl Storz box and I was told that this was an arthroscopy set ordered by Dr. Pandit. Dr Pandit was the HOD and had retired, so probably the arthroscopy set came after his retirement and nobody knew about it. So I started using the arthroscope and did lot of arthroscopies.
Once I got opportunity to do paediatric orthopaedics in Japan, things started to turn positively toward paediatric orthopaedics. The spectrum of disease in Japan was quite different from that in India. There the focus was on early detection, braces etc. Surgeries were performed but only for different diseases like osteogenesis imperfecta etc unlike the neglected and complex cases that we had in India. But my time in Japan gave me an introduction to paediatric orthopaedic world.
1985, Yokohama, Japan, with friends for life!
When I came back to Sion Hospital in 1986. my boss, Dr. S.S. Vengsarkar had resigned as HOD and Dr. N.S. Laud had taken over. Both encouraged me a lot. Dr Laud allotted me a side room with six paediatric orthopaedic beds. I told him that I wanted a separate paediatric orthopaedic OPD and he graciously agreed. We started this paediatric orthopaedic OPD in early 1986 and it was the first paediatric orthopaedic unit in any teaching hospital. We interacted with other paediatric faculties also. It was a flourishing OPD and was held every week. Apparently this OPD was later taken over by Joy Patankar later on. During this time in 1986 there was an advertisement for a post in Wadia Children’s Hospital for which I was selected. I had already completed 4 years in Sion by that time and so I decided to leave in 1987. I gave my resignation in February 1987. Dr Dalal who was the dean at Wadia hospital requested me to take up Dr Kumbhani’s OPD. I was not yet relieved from Sion, but I accepted the offer and started attending OPD from October of 1986 till February of 1987. In February I was relieved from Sion and started working at Wadia full time.
Another peculiar thing happened in February of 1987. There was a conference in Mumbai arranged by Dr Dholakia, named ‘Surgery in the Tropics’. Prof. Robert Owen from Liverpool University came for this conference and we were scheduled together for a symposium on Perthes disease on which Dr. Dholakia was also speaking. I was to speak on etiopathogenesis and Prof. Owen was to speak on the surgical aspect. Since I was very interested in paediatric orthopaedic I was continuously reading and before the conference Liverpool group had recently published their work on etiopathogenesis. I went through the paper and prepared my presentation. Prof. Owen thought that no one from India would be knowing about the study and so included some 20 slides of the etiopathogenesis in his surgery lecture, but then he had to rush through them as I had already covered them in my lecture. After the symposium was over, he asked me if I was interested in doing M.Ch at Liverpool. I did want to go to Liverpool but I said I would come only if I got a registrar job which could sustain me. I told him that I can’t come only as a student, pay fees and attend the course. He promised that he will do something and true to his promise he wrote back in 10 days offering me a student position for M.Ch. I again wrote back requesting for a job with the M.Ch. I got a reply from him inviting me for an interview for a job. He said if the interview board decides to give you a job, you can do both M.Ch and the job. In the interview they already had my CV, I had Japan experience and 5 years’ experience at Sion and Wadia hopital. Prof. Owen had retired but attended the interview board. I had opted to stay in YMCA dorm which was near the bus station of Liverpool. After the interview I was returning back to YMCA when somebody followed me and asked me to call on a number. He said Mr John Taylor wanted me to speak to him. Mr John Talylor was senior consultant and was chief of orthopaedic surgery at Alder Hey hospital. When I called him, he invited me for dinner, to which I gladly agreed. He took me to his house and he congratulated me on getting the job. He said this is the first time we are appointing anyone directly from India. We have given you the most prestigious job in Liverpool. I returned back to England in December 1987 to get used to the system. I had very good time at Liverpool. I had alternate day emergency on call and everyday 2 hours classes. This was quite a hectic schedule with almost every other night going on till late with surgeries the next morning and then followed up with OPD. There were classes every day and class assignments too. Fridays’ were totally off to attend M.Ch schedule where we had classes, visits to other hospitals, case presentations, workshops etc. I was seven years post MS and had maturity to grasp most of the things. So these two experiences, in Japan and England added a lot to my understanding. Some things are very different at these places specially their approach to education. For example if I had to use the library at Japan at the Yokohama Children’s Medical Centre(where I did my fellowship), I had to simply ask the keys from the security. I could go to the library anytime and read. If I had to borrow a book, I simply had to write my name in the card and drop in the box and take the book. In UK, if I needed any literature, I would simply ask the librarian and they would provide me with everything. This was unheard of in India at that time and it was extremely difficult to get literature. We had to visit many libraries and beg for articles and many a times they won’t have the article. When in UK, I continued my thesis on septic hip which I had started in India and wanted to make my M.Ch thesis. In India I did not find much literature and so I prepared my classification etc for the same. But in England while referencing and cross referencing I came across an article by Hunka on the topic. It wasn’t very popular article by somewhere in cross-referencing it was mentioned as Hunka’s criteria for septic hip. Then I knew that he had already published a classification in 1982.
The experience at Liverpool was very helpful and I believe a good impression was made of Indian students. I had a good experience already specifically in polio, so if anyone was stuck on some of these rare cases they would call me. Prof Klenerman was a great foot surgeon who worked at our hospital and whenever patients of polio would come to him, he would call me for opinion always. This created a good impression and probably made easy for future guys to join MCh. These experiences helped me a lot in grooming myself into paediatric orthopaedics.
End of 1988, Dr. Johari receiving the prestigious Norman Roberts Medal of the University of Liverpool
1988, England, Alder Hey Children’s Hospital with OPD staff
SP: How was the journey when you came back?
ANJ: So I came back to Wadia and also joined COH, JJ Hospital and Asha Parekh hospital as honorary. I juggled all of them for some time but found it quite taxing. I really wanted to be a full timer as I was of academic mind-set, so wanted to remain at an institute. But I found the environment at the Sion and other hospitals not very appealing. For everything we had to literally beg. What should logically follow in terms of education, academics and infrastructure had to go through lot of red tape, through HOD, Dean, AMC etc. This environment I found very frustrating and didn’t think I could spend my whole life in such environment. Meanwhile I had a conversation with Dr Dhir who was HOD at KEM Hospital. I asked him if he will be attending a forthcoming conference to which he replied that he was allowed to attend only two conferences from the corporation. They also were not allowed to buy books directly and had to go through library to buy anything. This strengthened my resolve to come out of the full time mode to join private practice rather reluctantly. I was very fond of reading, learning new things etc but had to give up full time
AKS: Did you ever think of staying back in UK.
ANJ: Somehow I never wanted to stay back in UK. They had good impression of me and would have created an opportunity for me, but I felt a bit misplaced there. Misfit in the sense you have to be always in your best behaviour and use fork and knife etc [laughs]. I always thought I belonged here and I didn’t want to stay there.
Dr. Johari with a patient in his clinic – where children are his love and excellence his passion…
When I came back I was just doing honorary job at various places. My wife questioned me on my intentions to continue as honorary at various places and earn paltry honorarium. I used to get around 125 rupees from JJ Hospital, 50 from Wadia, 200 rupees from COH with total of 500 rupees a month. With these pressures I decided to enter private practice and the next part of my journey is about being full-fledged private paediatric orthopaedic surgeon and being involved in promoting the speciality of Paediatric Orthopaedics in India. Its again a very interesting story that involves birth of Paediatric Orthopaedic Society of India (POSI)
We will continue the story further in the part two of the interview, to be published in the forthcoming issue of IJPO
Dr. Johari with his wife Dr. Usha, an ophthalmologist …Through thick and thin, together!
Dr Ashok N Johari
(Abstract) (Full Text HTML) (Download PDF)
Novel Method of Treating Elevated Compartment Pressures Post Intraosseous Cannulation of Tibia
Volume 2 | Issue 2 | May-Aug 2016 | Page 38-40|Eamon O Ceallaigh, Francis O’Neill, Jim Kennedy, Jacques Noel
Authors :Eamon O Ceallaigh [1], Francis O’Neill [2], Jim Kennedy [2], Jacques Noel [2]
[ 1] Mater Misericordiae University Hospital,Dublin Ireland
[2] Our Lady’s Children’s Hospital Crumlin, Dublin Ireland
Address of Correspondence
Dr Eamon O’Ceallaigh
Our Lady’s Children’s Hospital Crumlin, Dublin Ireland
Email: eamonoceallaigh@rcsi.ie
Abstract
Introduction: Vascular access is a vital task in the resuscitation of a critically ill child. Although peripheral intravenous access is the traditional method for gaining vascular access, this can be challenging in patients with circulatory collapse.
Today IOI (Intra Osseous Infusion) is accepted as standard equipment on paediatric and adult rescue carts. IOI is recommended in Advanced Cardiac Life Support and Pediatric Advanced Life Support treatment protocols as alternative means of vascular access in the event that IV cannulation is delayed or not feasible. The conventionally recommended site for IOI is the proximal tibia.
Case Report: We report the case of a 6 month old boy with meningococcal septicaemia who was admitted to ICU for resuscitation that had an attempted intraosseous cannulation in his left leg with intravenous fluids administered in the ambulance en route. On arrival at the hospital, it was noted that the left foot was swollen and tense and an alternative site for administration of fluids was obtained. An orthopaedic review was sought for possible compartment syndrome left foot. Stryker needle measurements of intracompartmental pressures within the foot were elevated. The decision was then made to apply an eschmark bandage to the left foot and lower leg and to elevate the leg for 2-3 minutes with this in place. After removing the eschmark bandage, the intracompartmental pressures were remeasured and found to have returned to acceptable levels.
Conclusion: We believe that if compartment syndrome is being considered because of the clinical examination and/or elevated intracompartmental pressures in patients post IOI, it may be worth employing this technique with the eschmark bandage before proceeding to surgical decompression as this technique is far less invasive than surgical decompression and if successful, as in this case, can lower intracompartmental pressures quite significantly and quickly.
Keyword: Paediatrics, Orthopaedics, Resuscitation, Musculosketelal
Introduction
Vascular access is a vital task in the resuscitation of a critically ill child.[1,2] Although peripheral intravenous access is the traditional method for gaining vascular access, this can be challenging in patients with circulatory collapse and it has been demonstrated that experienced emergency department personnel can require more than 10 minutes to gain IV access in such cases[3].
Tocantins and O’Neill established in 1941 that the bone marrow cavity of a long bone was a possible site of vascular access and in the 1940s[4] and early 1950s, Intra Osseous Infusions (IOI) were used extensively in children who required repeated blood transfusions and antibiotic therapy[5] IOI has also been shown by radionucleotide technique to deliver fluids as rapidly as intravenous techniques [6] However intraosseous infusion fell out of popularity in the 1950s due to the advent of plastic IV catheters.[5]
Today IOI is accepted as standard equipment on paediatric and adult rescue carts. IOI is recommended in Advanced Cardiac Life Support and Pediatric Advanced Life Support treatment protocols as alternative means of vascular access in the event that IV cannulation is delayed or not feasible.[2,7]
Studies have demonstrated that the use of IOI can decrease the time needed to obtain vascular access in paediatric patients in cardiac arrest.[8,9] and that the rate of vascular access in paediatric cardiac arrest patients is higher for IOI (83%) than for all other forms of IV access.[10]
However, there are potential complications associated with IO infusion and these include osteomyelitis, cellulitis, fracture at IO-line site, compartment syndrome, and fat embolism. [14,15,16,17]
It is the complication of compartment syndrome that we would like to discuss further in this case report.
Case Report
We report the case of a 6 month old boy with meningococcal septicaemia who was admitted to ICU for resuscitation. While in the ambulance on route to the hospital, paramedics had attempted an intraosseous cannulation in the child’s left leg. Uncertainty exists as to whether the cannula was correctly sited but intravenous fluids were administered through this cannula. On arrival at the emergency department, it was noted that the left foot was swollen and tense and an alternative site for administration of fluids was obtained. After resuscitation and admittance to ICU, the orthopaedic team were asked to review the patient with regard to a swollen discoloured left foot. The child was fully intubated and otherwise stable at this stage. On examination, the left foot was swollen and tense to palpation. There was good capillary refill in all the toes and a dorsalis pedis pulse was palpable. It was impossible to assess discomfort or pain in the foot at this stage as the child was fully intubated. As a full clinical examination was not possible due to the clinical condition of the child, it was decided to use a stryker needle to measure intracompartmental pressures within the foot with the intention of determining if there was a case for compartment syndrome in the foot. It is now accepted that there are 9 compartments within the foot[12] The stryker was initially placed perpendicular to the skin at the medial aspect of the foot, at the base of the first metatarsal and only advanced 1cm approx to measure the medial compartment. Once that measurement was taken, the needle was subsequently advanced deeper to measure the pressure within the central compartment. One measurement was taken laterally from the lateral compartment. Due to the small size of the foot and relatively large size of the needle, it was decided against individually measuring the other remaining compartments as there would be multiple large puncture wounds in a relatively small foot. A collective measurement was taken from the dorsal aspect of the foot and we are aware that this may not accurately represent the instrinsic compartments. Initial measurements with the stryker needle revealed that the intracompartmental pressure on the dorsal aspect of the foot was 15mmHg while the pressure on the plantar aspect of the foot (medial, central, lateral) was 37mmHg and this result was confirmed by 2 different individuals independently measuring compartment pressures within the foot. Diastolic blood pressure at the time of measurement of the compartment pressures was 56mmHg.
Compartment Syndrome can be considered when the pressure difference between diastolic blood pressure and intracompartmental pressure is less than 30mmHg or also when absolute interstitial pressure is greater than 30mmHg.
The decision was then made to apply an eschmark bandage to the left foot and lower leg and to elevate the leg for 2-3 minutes with this applied. The reason for attempting this course of action was that we had reasoned that the raised intracomparmental pressure was the direct result of the fluid that had leaked into the soft tissues within the compartment after the administration of fluid through the incorrectly sited IOI cannula and that by applying the eschmark bandage, we may be able to force some of this fluid out of the compartment and back into the vascular system.
Once the eschmark bandage was removed, the intracompartmental pressures within the foot were again measured with the stryker needle. These results revealed an improvement in pressures with the dorsal compartment reading 12mmHg and the pressure recorded on the plantar aspect of the foot (medial, central and lateral compartments) reducing to 21mmHg. The diastolic blood pressure was 58mmHg while these repeat measurements were being taken. This measurements was taken twice to help ensure that they was accurate. Clinically, the foot also looked better and was less tense to palpation. The foot was subsequently elevated and monitored. The foot continued to improve clinically and surgical decompression for compartment syndrome was not necessary.
Discussion
Intra Osseous Infusion is a proven method of delivering urgently needed fluids to a patient and this method of delivery works because the rich vasculature of long bones transports the fluids and medications to the central circulation. Sinusoids within the marrow of long bones function as rigid conduits that do not collapse in the presence of hypovolemia. Blood passes into the venous channels of the medulla and then leaves the bone through nutrient or emissary veins entering the general circulation.
The conventionally recommended site for IOI is the proximal tibia[2] The tibial tuberosity should be located by palpation just below the patella and the recommended insertion site is the relatively flat area approximately 2cm distally and slightly medial to the tibial tuberosity. Although this site is usually distal to the growth plate, it is still recommended that the needle be angled 10–15 degrees caudally to avoid injury to the growth plate. The patient’s leg should be restrained and a small sandbag placed under the knee. The area should be cleaned and draped using sterile technique. Proper IO placement in the marrow canal can be confirmed by three methods. First, the needle should stand on its own without support. Second, after unscrewing the inner trocar from the needle, bone marrow should be able to be aspirated through the needle. Third, a 5–10-mL saline bolus injection should enter with little resistance and without evidence of extravasation; this can be confirmed by carefully observing the calf area for acute swelling or discoloration. Only one IO attempt should be made in each bone. Multiple punctures in the periosteum may result in extravasation of fluid into the soft tissues. However, if the needle becomes plugged with soft tissue, it may be removed, and a new needle may be inserted through the same cannulation site.[11]
It is recommended that IO needles should not be placed at fractured extremities because extravasation will occur at fracture sites. The tibia and distal femur are recommended sites in infants and children younger than 6 years. These sites are easily identified by topical landmarks, and the bones are superficially located. Needles inserted in these locations traverse tissue planes devoid of important structures, and the marrow cavity is relatively large. These sites are also physically removed from other resuscitative efforts, such as airway management and chest compressions. Also it is worth noting that secure vascular access should be obtained before the functioning IO needle is removed.
As this case report demonstrates, compartment syndrome can become a complication of IO insertion and this has been previously reported [14,15,17]. We speculate that this resulted primarily from extravasation of fluid into the muscular compartments. The potential causes for this extravasation include incomplete penetration of the cortex, penetration of the needle through the posterior aspect of the cortex, extravasation through a previous IO puncture site, and extravasation through the foramina of the nutrient vessel [17]
Precautionary measures that reduce the incidence of compartment syndrome and allow for its early recognition include correct placement of the IO line to reduce the amount of fluid extravasation. A fresh, large-bore needle should be used to facilitate bone penetration, prevent blockage of the lumen, and withstand bending forces. Multiple breaches of the cortex should be avoided, and the needle should be passed only through the near cortex. Aspiration of marrow contents confirms accurate placement, and free flow of fluid into the osseous cavity should be noted. Plain radiographs can also be used to confirm placement. If improper placement is confirmed, and the cortex has been breached, the site should be well dressed, and insertion can be attempted at another site. It is important that the affected limb be immobilized during use of the IO line to prevent dislodgement of a properly placed needle. The cannula should be secured to the extremity with a noncircumferential dressing to prevent. If possible, the circumference of the extremity at the level of the IO site should be measured serially. Although not immediately life-threatening, IO-line complications can be associated with extensive morbidity. If there is any concern that compartment syndrome is developing, the IO line should be removed immediately, and the appropriate surgical or orthopaedic service should be consulted.
We believe that if compartment syndrome is being considered because of the clinical examination and/or elevated intracompartmental pressures in patients post IOI, it may be worth employing this technique before proceeding to surgical decompression. If successful, as in this case, can lower intracompartmental pressures quite significantly and quickly. Whilst we do not anticipate any major complications unique to this technique, if it is unsuccessful and surgical decompression is delayed the patient may develop the complications of late compartment syndrome. As such, we would advise very close clinical monitoring post-bandage application and low threshold for surgical decompression if the compartment pressures do not lower quickly. If the compartment syndrome is not due to extravasation post IO insertion, we would not expect this technique to work and surgical decompression would most likely be needed.. As such, we are not suggesting this novel technique is a panacea for compartment syndrome but should only be considered in a patient who has developed compartment syndrome post IO insertion and does not have another likely cause for compartment syndrome.
Unfortunately, given the emergent nature of our case, we are unable to provide photographic evidence of our novel treatment as patient care and treatment was the priority at the time and the idea of case report was formulated afterwards. We would like to confirm however that we stand over the authenticity of the case.
We would like to report this technique with the eschmark bandage for lowering intracompartmental pressures in cases of extravasation of fluid into the soft tissue in the case of IOI before proceeding with surgical decompression. This technique is far less invasive than surgical decompression and if the pressure can be lowered significantly, as in this case, the need for proceeding to surgical decompression can be negated.
References
1. Hazinski MF, Cummins RO, Field JM (eds).Basic life support for health care providers. In: Handbook of Emergency Cardiovascular Care for Healthcare Providers. Dallas TX: American Heart Association, 2002, pp 1-2, 96.
2. American College of Surgeons (eds). ATLS, Advanced Trauma Life Support for Doctors, Student Manual. Chicago IL: American College of Surgeons, 1997, pp 12, 97.
3. Rosetti V, Thompson BM, Aprahamian C, Darin JC, Mateer JR. Difficulty and delay in intravascular access in pediatric arrests [abstract]. Ann Emerg Med. 1984;13:406.
4.Tocantins L, O’Neill J. Infusions of blood and other fluids into the general circulation via the bone marrow. Surg Gynecol Obstet. 1941;73:281-7.
5. Rosetti VA, Thompson BM, Miller J, Mateer JR, Aprahamian C. Intraosseous infusion: an alternative route of pediatric intravascular access. Ann Emerg Med. 1985;14:885-8.
6. Cameron JL, Fontanarosa PB, Passalaqua AM. A comparative study of peripheral to central circulation delivery times between intraosseous and intravenous injection using radionucleotide technique in normovolemic and hypovolemic canines. J Emerg Med. 1989;7:12
7. Chameides L, Hazinski MF (eds). Intraosseous Cannulation. In: Textbook of Pediatric Advanced Life Support. Dallas TX: American Association of Pediatrics–American Heart Association,
1994, pp 5-6.
8. Glaeser PW, Losek JD, Nelson DB, et al. Pediatric intraosseous infusions: impact on vascular access time. Am J Emerg Med. 1988;6:330-2.
9. Kanter RK, Zimmerman JJ, Strauss RH, Stoeckel KA. Pediatric emergency intravenous access: evaluation of a protocol. Am J Dis Child. 1986;140:132-4.
10. Brunette DD, Fischer R. Intravenous access in pediatric cardiac arrest. Am J Emerg Med. 1988;6:577-9.
11. Neal CJ, McKinley DF. Intraosseous infusion in pediatric patients. J Am Osteopath Assoc. 1994;94(1):63-6.
12. Manoli A 2nd, Weber TG. Fasciotomy of the foot: an anatomical study with special reference to release of the calcaneal compartment. Foot Ankle 1990;10:267-75.
13. Launay F, Paut O, Katchburian M, Bourelle S, Jouve JL, Bollini G. Leg amputation after intraosseous infusion in a 7-month-old infant: a case report. J Trauma. 2003;55(4):788-790.
14. Vidal R, Kissoon N, Gayle M. Compartment syndrome following intraosseous infusion. Pediatrics. 1993;91(6):1201-1202.
15. Burke T, Kehl DK. Intraosseous infusion in infants. Case report of a complication. J Bone Joint Surg Am. 1993;75(3):428-429.
16. Günal I, Köse N, Gürer D. Compartment syndrome after intraosseous infusion: an experimental study in dogs. J Pediatr Surg. 1996;31(11):1491-
1493.
17. Galpin RD, Kronick JB, Willis RB, Frewen TC. Bilateral lower extremity compartment syndromes secondary to intraosseous fluid resuscitation.
J Pediatr Orthop. 1991;11(6):773-776.
Dr Eamon O Ceallaigh
(Abstract) (Full Text HTML) (Download PDF)
Clinical and Radiological Outcome following Kim’s Step cut Translation Osteotomy for Cubitus Varus and Valgus in Children
Volume 2 | Issue 2 | May-Aug 2016 | Page 34-37|Dhurvas Ramlal Ramprasath, Vasudevan Thirunarayanan, Murugan Shanmuga Sundaram
Authors :Dhurvas Ramlal Ramprasath [1], Vasudevan Thirunarayanan [1], Murugan Shanmuga Sundaram [2]
[1] Senior Assistant Professor, Department of Orthopaedic Surgery, Government Royapettah Hospital,Westcott road,Royapettah,Chennai,India-600014.
[2] Junior Resident, Department of Orthopaedic Surgery, Government Royapettah Hospital, Chennai, India- 600014.
Address of Correspondence
Dr Ramprasath D.R.,
12/23, Murugappa street, Purasawakkam, Chennai, India. PIN- 600007.
Email ID: dhurvasramprasath@gmail.com
Abstract
Several osteotomies are available to correct cubitus varus and valgus deformities in children. The purpose of this study was to evaluate clinical and radiological outcome following Kim’s step cut translation osteotomy for such deformities.
Materials and Methods: We have instituted Kim’s step cut translational osteotomy in seven children having deformities of elbow (cubitus varus – 4 and cubitus valgus – 3). Patients were followed up for a period of 8 to 14 months during the period of August 2014 to October 2015. Clinically and radiologically, preoperative and postoperative Humerus-Elbow-Wrist angle, Range of motion of elbow, Lateral/Medial Prominence Index and neurological examination for ulnar nerve were determined. Results were evaluated according to modified Oppenheim et al criteria.
Results: The mean postoperative Humerus-Elbow-Wrist angle in patients with cubitus varus was 8.5±2.06 0 (range, 50 to 100). The mean improvement in Lateral Prominence Index was 7.4 ±1.28% (from –13.15% to -5.75% ). In cubitus valgus patients, mean
postoperative Humerus-Elbow-Wrist angle was 12.33±3.510(range, 80 to 150) . The mean improvement in MPI was 8.7±0.83% (from -15.5% to -6.8% ) . In all patients range of motion was comparable with normal side elbow. Bone union was achieved in all patients. According to Oppenheim’s criteria, six patients had excellent results and one patient had good result. .None of them had any complications.
Conclusion: Even though multiple procedures are available for correcting deformities of elbow, Kim’s step cut translational osteotomy provides good correction angle, lesser prominence of the condyle, better stability and three dimensional correction.
Key Words: Cubitus varus, Cubitus valgus, Kim’s osteotomy, Lateral/ Medial prominence Index.
Introduction
Cubitus varus and valgus deformities are complications of elbow fractures in children[1]. Cubitus varus has multiple components that include varus malalignment, hyperextension and internal malrotation[2,3]. The most important indication for osteotomy is to achieve a good cosmesis[2,4]. Many surgical techniques have been described to correct these deformities including closing wedge, opening wedge, dome and step cut osteotomies[5-12]. The closing wedge osteotomy has a tendency to produce prominent condyles after correction,often compromising the cosmetic outcome[2,13-16]. The inclusion of translation in the osteotomy improves cosmetic appearance by minimizing the persistent prominence of the medial or lateral condyle. This can be achieved by Kim’s osteotomy. The aim of our study was to evaluate clinically and radiologically, the preoperative and postoperative Humerus-Elbow-Wrist(HEW) angle, Lateral/Medial Prominence Index(LPI/MPI), Range of Motion(ROM), in children undergoing Kim’s step cut translation osteotomy for cubitus varus and valgus.
Materials and Methods
This is a retrospective study, from August 2014 to October 2015, involving seven paediatric patients in the age group 8 – 14 years with male:female ratio of 4:3. Those with cubitus varus deformity had sustained supracondylar humerus fracture and those with valgus deformity had fracture lateral condyle. All the patients had undergone native treatment immediately after injury, and presented to our department after a period of 14 months to 34 months after injury.
We have instituted step cut translational osteotomy of Hui Taek Kim [1] in all the seven patients. Preoperatively, radiological and clinical planning includes measurement of HEW angle, lateral/medial prominence index (using the method described by Wong et al [2,16]),range of motion of elbow, neurological examination for ulnar nerve and internal rotation malalignment (using the method described by Yamamoto[17,18]). Same radiological and clinical parameters were evaluated postoperatively.
HEW angle was measured by drawing two lines, one line along the anatomical axis of humerus ,and another line joining midpoints of two transverse lines(one proximal and one distal) across the forearm that connected the medial cortex of ulna and lateral cortex of radius (Fig-1). The Lateral/Medial Prominence Index was measured by using the formula shown in (Fig-2).
We determined the Correction Angle (CA) for patients with cubitus varus by adding varus HEW angle with normal side HEW angle, and for patients with cubitus valgus by subtracting normal side HEW angle from affected side valgus HEW angle. A template using X-ray film, was prepared preoperatively, to mark the site and size of osteotomy, using following technique(Fig-3).
The outline of the bone was drawn on a trace paper. A horizontal line was drawn perpendicular to anatomical axis of humerus at a level 0.5 to 1 cm proximal to the olecranon fossa. Now the trace paper was cut along the horizontal line and the distal fragment was rotated laterally and translated medially(in case of cubitus varus) so as to achieve HEW angle of normal side. Vice versa was done for cubitus valgus deformity. An inverted V was marked on the trace paper. We then cut out the triangular overlapping area from the paper and prepared X-ray film of same size and shape. This triangular X-ray film was sterilised for
use during osteotomy.
Figure 1: Humerus-Elbow-Wrist (HEW) Angle
Figure 2: Lateral/Medial Prominence Index % (LPI/MPI)
LPI (%)=(AB-BC)/AC×100
LPI (%)=(AB-BC)/AC×100
Figure 3: Preop Templating
Method of Osteotomy
With the patient in lateral decubitus position,through posterior approach ,ulnar nerve was isolated and protected. The triceps aponeurosis was split. The triangular X-ray template (turned face downward because of posterior approach) was placed over the bone 1cm proximal to olecranon fossa and necessary osteotomy was done to remove an identical piece of bone. The distal fragment was rotated laterally for cubitus varus(and medially for cubitus valgus) and inserted into the inverted V shaped defect. The deformity correction was assessed clinically and then the fixation was done with distal radius T-Plate and 3.5mm cortical
screws. The ulnar nerve was transposed anteriorly in patients who had tardy ulnar nerve palsy due to cubitus valgus deformity.
Patient was immobilised in long arm slab for 2 weeks following which active and assisted mobilisation was done intermittently retaining the splint until radiological union was achieved.
Results
The HEW angle, LPI/MPI, ROM were measured and analysed (Table -1).
Table-1: Preoperative and Postoperative Measurements.
HEW- Humerus-Elbow-Wrist angle, LPI /MPI – Lateral/Medial Prominence Index, CA- Correction Angle
In cubitus varus patients, mean postoperative HEW angle was 8.50(range, 50to 100),with mean correction of 21.50(range,190 to 250). The mean improvement in LPI was 7.4% (from -13.15% to -5.75% ) .In cubitus valgus patients(Fig-5), mean postoperative HEW angle was 12.330(range, 80 to 150),with mean correction of 21.660(range,200 to 230). The mean improvement in MPI was 8.7% (from -15.5% to -6.8% ).In all patients, range of motion was comparable with normal side elbow (Table 1). Pronation and supination movements were normal in all our cases. Bone union was achieved in all patients.
Figure 4: Osteotomy and Fixation
Figure 5: X-ray(Preop and Postop)
According to Oppenheim’s criteria [7], excellent result (Fig-6) was achieved in 6 patients and good result in one patient, and no patient had poor result.
Figure 6: Lateral/Medial Prominence Index % (LPI/MPI)
Discussion
In patients with cubitus varus/valgus, the following problems need to be addressed deformity correction in coronal plane(valgus/varus), sagittal plane(fixed flexion/hyperextension),horizontal plane(internal/external rotation deformity); ulnar nerve palsy, if any.
The deformity is better corrected during childhood. Correction, particularly in cubitus varus, in adult is challenging due to mature skeleton, inherent instability at osteotomy site, risk of delayed union/non union, implant failure, infection, stiffness and neurovascular complications [19]. A rough estimate will be around a year after original injury. Again patient demands, growth potential and status of physis should be taken into account while planning surgery[20].
Major types of osteotomies are – simple closing wedge [17,21,22],step cut translation [1,17,23], dome rotational osteotomy[13,14,17,24] and spike translation osteotomy[17]. Many of these osteotomies have got their own disadvantages, like lateral scar, medial and lateral condylar prominence and difficulty in correcting rotational deformities( due to contractures)[1,24,25,26].
Various method of fixation include use of K-wires, screws, plates and external fixators (Ilizarov technique) [5,13,25,27-29]. We have used Kim’s method of step cut translation Osteotomy, and fixed with distal radius T-plate.
This method has got multiple advantages. Adequate Correction Angle (CA) is achieved by moving the apex more medially (in cubitus varus) or laterally (in cubitus valgus). The stability of fixation is enhanced because the distal fragment is inserted into the inverted V shaped proximal fragment and fixation was done with plates. The prominence of condyles (lateral condyle in cubitus varus and medial condyle in cubitus valgus) is less with Kim’s osteotomy (when compared to other methods ) because distal fragment is translated. With Kim’s osteotomy, three dimensional correction is possible. The correction of internal rotation is recommended when the difference in rotational alignment in both sides is greater than 100 [1,17,18]. In our study ,we did not encounter patient with hyperextension, or internal rotation more than 100, when compared to normal side. Hence we have not attempted correction in sagittal/horizontal planes.
The limitations of our study is smaller sample size and follow up of only 14 months duration.
Conclusion
This simple step cut translation osteotomy(Kim’s) results in good cosmetic deformity correction,very firm fixation,earlier elbow movement and also avoids problems of condylar prominence and non union. Deformities in sagittal/horizontal plane can also be corrected.
References
1. Hui taek kim, md, Jung sub lee, md, and Chong il yoo, md. Management of cubitus varus and valgus. The journal of bone & joint surgery.Volume 87-a , number 4, april 2005.
2. K. Bali , P. Sudesh, V. Krishnan, A. Sharma, S.R.R. Manoharan, A.k. Mootha. Modified step-cut osteotomy for post-traumatic cubitus varus: our experience with 14 children. Orthopaedics & traumatology: surgery & research (2011) 97, 741-749.
3. Takagi T, Takayama S, Nakamura T, Horiuchi Y, Toyama Y,Ikegami H. Supracondylar osteotomy of the humerus to correct cubitus varus: Do both internal rotation and extension deformities need to be corrected? J bone joint surg am 2010;92(7):1619-26.
4. Pankaj A, Dua A, Malhotra A, Bhan S. Dome osteotomy for posttraumatic Cubitus varus a surgical technique to avoid lateral condylar prominence. J pediatr orthop 2006;26(1):61-6.
5.Y.H. Yun,S.J. Shin,J.G. Moon. Reverse v osteotomy of the distal humerus For the correction of cubitus varus. J bone & joint surg [br].2007;89-b:527-31.
6.Derosa GP, Graziano GP. A new osteotomy for cubitus varus. Clin orthop 1988;236:160-5.
7. Kanaujia RR, Ikuta Y, Muneshige H, Higaki T, Shimogaki K. Dome osteotomy for cubitus varus in children. Acta orthop scand 1988;59:314-17.
8. Kim HS, Jahng JS, Han DY, et al. Modified step-cut osteotomy of the humerus. J Pediatr orthop b 1988;7:162-6.
9. Koch PP, Exner GU. Supracondylar medial open wedge osteotomy with external fixation For cubitus varus deformity. J pediatr orthop b 2003;12:116-22.
10. Laupattarakasem W, Mahaisavariya B, Kowsuwon W, Saengnipanthkul S. Pentalateral osteotomy for cubitus varus: clinical experiences of a new technique. J Bone joint surg [br] 1989;71-b:667-70.
11. Oppenheim WL, Clader TJ, Smith C, Bayer M. Supracondylar humeral osteotomy For traumatic childhood cubitus varus deformity. Clin orthop 1984;188:34-9.
12. Uchida Y, Ogata K, Sugioka Y. A new three-dimensional osteotomy for cubitus Varus deformity after supracondylar fracture of the humerus in children. J pediatr Orthop 1991;11:327-31.
13. Bellemore MC, Barrett IR, Middleton RW, Scougall JS, Whiteway DW. Supracondylar osteotomy of the humerus with correction of cubitus varus. J bone joint surg br 1984;66(4):566-72.
14. Matsushita t, Nagano a. Arc osteotomy of the humerus to correct cubitus varus. Clin orthop relat res 1997;336:111-5.
15. Tien YC, Chih HW, Lin GT, Lin SY. Dome corrective osteotomy for cubitus varus deformity. Clin orthop relat res 2000;380:158-66.
16.Wong HK, Lee EH, Balasubramaniam P.The lateral condylar prominence. A complication of supracondylar osteotomy for cubitus varus. J bone joint surg br 1990;72:859-61.
17. Ali Moradi MD, Ehsan Vahedi MD,Mohammad H.Ebrahimzadeh MD. Spike Translation: A New Modification in Step-cut Osteotomy for Cubitus Varus Deformity. Clin Orthop Relat Res (2013) 471:1564–1571.
18. Yamamoto I, Ishii S, Usui M, Ogino T, Kaneda K. Cubitus varus deformity following supracondylar fracture of the humerus: a method for measuring rotational deformity. Clin Orthop Relat Res. 1985;201:179–185.
19. S Pandey, A Shrestha, AP Regmi, A Prajapati, S Dhakal and G Neupane. Cubitus varus in young adults correction with lateral closing wedge osteotomy and screw, k-wire and ss-wire fixation.Journal of Chitwan Medical College; 2012, 1(2); 60-62.
20. Sandeep patwardhan , Ashok k shyam. Cubitus varus deformity – rationale of treatment and methods. International journal of paediatric orthopaedics | volume 1 | issue 1 | july-sep 2015 | page 26-29.
21. Graham B, Tredwell SJ, Beauchamp RD, Bell HM. Supracondylar osteotomy of the humerus for correction of cubitus varus. J Pediatr Orthop. 1990;10:228–231.
22. Voss FR, Kasser JR, Trepman E, Simmons E Jr, Hall JE. Uniplanar supracondylar humeral osteotomy with preset Kirschner wires for posttraumatic cubitus varus. J Pediatr Orthop. 1994;14:471–478.
23. Davids JR,Lamoreaux DC, Brooker RC,Tanner SL, Westberry DE.Translation step-cut osteotomy for the treatment of posttraumatic cubitus varus.J Pediatr Orthop. 2011;31:353-365
24. Labelle H, Bunnell WP, Duhaime M, Poitras B. Cubitus varus deformity following supracondylar fractures of the humerus in children. J Pediatr Orthop. 1982;2:539–546.
25. French PR. Varus deformity of the elbow following supracondylar fractures of the humerus in children. Lancet. 1959;2:439-41.
26. King D, Secor C. Bow elbow (cubitus varus). J Bone Joint Surg Am. 1951; 33:572-6.
27. Carlson CS Jr, Rosman MA. Cubitus varus: a new and simple technique for correction. J Pediatr Orthop 1982;2:199-201.
28. Levine MJ. Horn BD, Pizzutillo PD. Treatment of posttraumatic cubitus varus in pediatric population with humeral osteotomy and external fixation. J Pediatr Orthop 1996;16:597-601.
29. Karatosun V, Alekberov C, Alici E, Ardic CO, Aksu G. Treatment of cubitus varus using the Ilizarov technique of distraction osteogenesis. J Bone Joint Surg [Br]2000;82-B:1030-3.
Dr Dhurvas Ramlal Ramprasath
Dr. Vasudevan Thirunarayanan
Dr. Murugan Shanmuga Sundaram
(Abstract) (Full Text HTML) (Download PDF)
Pollicisation: Embryology, History, Technique and Results
Volume 2 | Issue 2 | May-Aug 2016 | Page 29-33|Amita S. Hiremath, Binita N. Raut, Amit A. Yadav, Mukund R. Thatte
Authors :Amita S. Hiremath [2], Binita N. Raut [1], Amit A. Yadav [2], Mukund R. Thatte [3]
[1] KLE University’s J.N.Medical College,Belgavi,
[2] Bombay Hospital and Institute of Medical Sciences Mumbai.
[3] Bombay Hospital and Institute of Medical Sciences Bai Jerbai Wadia Hospital for Children, Shushrusha Citizens’ Co‑op. Hospital,Maharashtra, India
Address of Correspondence
Dr Mukund R. Thatte, Room 6, 2nd Floor, New Wing, Bombay Hospital, New Marine Lines, Mumbai ‑.400 020, Maharashtra, India.
E‑mail: mthatte@gmail.com
Abstract
Thumb hypoplasia/aplasia is one of the components of radial longitudinal deficiency. It can occur either alone or it may be associated with other components of radial longitudinal deficiency. Aim of thumb reconstruction is to provide a functional and stable thumb which will improve the grip and aesthetic appearance of hand. Pollicisation is the treatment for Type IIIB,IIIC, IV and V types of thumb hypoplasia as per Blauth’s Classification as Modified by Manske and Buck-Gramcko. In the opinion of the authors, pollicisation is one of the finest and most difficult operations in reconstructive hand surgery.
Keywords: Pollicisation: History, Principles and Surgical technique.
Introduction
Napier has said “The hand without a thumb is at worst, nothing but an animated fish-slice, and at best a pair of forceps whose points don’t meet properly”. [1]
Thumb hypoplasia is a congenital condition, which can range from slightly small digit to deficiency of some musculotendinous units or osseous components to complete absence of thumb.40% of the hand function relies on a strong thumb. [2]For proper functioning of the hand, thumb size, its position,mobility and the relation with other fingers is critical. Children with thumb hypoplasia can manipulate small objects using side to side pinch, between adjacent digits, ‘Chopstick’ action; but it is difficult to grasp large objects. [3]
Thumb hypoplasia/aplasia is one of the components of radial longitudinal deficiency. It can occur either alone or it may be associated with other components of radial longitudinal deficiency. A wide range of manifestations on the preaxial side of the upper limb is seen in radial longitudinal deficiency. Hence, in any case of thumb hypoplasia, one should examine proximal forearm and contralateral thumb.
Incidence
Thumb hypoplasia is a component of various congenital malformations like thumb duplication, transverse deficiencies, brachydactyly, symbrachydactyly, cleft hand complex, constriction ring syndrome etc., and hence it is very difficult to find out the true incidence of thumb hypoplasia alone. Tay SC et al in 2006, reported upto 16% incidence of thumb hypoplasia amongst congenital hand deformities. [4] There is equal distribution of cases between male and female. About 60% cases have bilateral involvement with often asymmetrical involvement. [5] In unilateral cases, right hand is more commonly affected. [6]
In a study by Abdel-Ghani and Amro, [7] 86% cases of thumb hypoplasia were associated with various conditions involving cardiovascular, gastrointestinal and genitourinary system. Various conditions commonly seen in association with thumb hypoplasia are Holt-Oram syndrome, VACTERL association, Fanconi’s anaemia, Thrombocytopenia absent radius(TAR) syndrome. [6] The severity of radial longitudinal deficiency is directly proportional to the degree of thumb hypoplasia according to James et al. [8]
Genetics
The upper limb bud appears at 4th week of embryonic development opposite the caudal cervical somites. Various signalling centres have been identified that are responsible for upper limb development. [4,8]
1. Apical Epidermal Ridge(AER) – responsible for proximal to distal development (shoulder to hand) and is mediated by number of fibroblast growth factors.
2. Zone of Polarizing Activity (ZPA) – responsible for anterior-posterior pattern formation(also called Pre and Post Axial) and is mediated by sonic hedgehog (Shh) and homeobox (HOX) gene products.
3. WNT7a signalling centre – responsible for dorsal ventral development.
The exact mechanism of embryologic insult that leads to thumb hypoplasia is unclear. Abnormalities in AER or ZPA can lead to thumb hypoplasia. Studies have proved that administration of teratogenic agents or inactivating fibroblastic growth factors in rats and mice can lead to radial longitudinal hypoplasia with thumb hypoplasia. [10]
The deletion of chromosome 22q11 can lead to thumb hypoplasia in radial longitudinal deficiency [5]. However, it is difficult to point out single gene or enzymatic defect as the cause for thumb hypoplasia [8].
Classification
Thumb hypoplasia can present with wide range of functional and aesthetic differences. Hence careful inspection and examination is required. One should carefully examine the size, position, skeletal components, intrinsic and extrinsic muscles, joint stability, and first web space and associated conditions. One should correlate soft tissue and skeletal deficiencies while taking decision about the treatment.
Classification helps in taking decision about the treatment. In 1937, Muller first classified thumb hypoplasia. It is currently the Blauth’s classification which is widely accepted in classifying and as a guide for surgical planning. Manske further classified type 3 hypoplasia in A and B depending on stability of CMC joint. [4, 11]
Blauth’s Classification as Modified by Manske and Buck-Gramcko:
Type I: Mild hypoplasia
Slight decrease in thumb size
Slender phalanges and metacarpals
Normal intrinsic muscles
Normal trapezium, scaphoid, distal radius and styloid process
Type II: Moderate hypoplasia
Underdeveloped or absent thenar muscles
Adducted posture- first web space narrowing
Ulnar Collateral ligament (UCL) insufficiency at MP joint
CMC stable
Type III: Severe hypoplasia
All the features of type II plus
Radial carpal aplasia
Extrinsic muscle and tendon abnormalities
Type III A: Stable CMC joint
Type III B: Unstable CMC joint
Type IIIC: Buck Gramcko has added this variation in which thumb has only metacarpal with no musculotendinous unit and a wider skin bridge
Type IV: Pouce floutant (French Floating thumb)
Thumb is small and has rudimentary skeletal elements. It is an unstable digit, connected to the hand by only a skin bridge containing the neurovascular bundle.
Type V: Aplasia i.e.Absence of all thumb structures and radial carpal bones
Figure 1: Preoperative picture of Type IV thumb hypoplasia (volar view)
Figure 2: Preoperative picture of Type IV thumb hypoplasia (dorsal view)
Figure 3: Preoperative xray showing rudimentary skeletal elements
Evaluation
Thumb hypoplasia can be the only presentation of radial longitudinal deficiency or it may be associated with other anomalies. Plain bilateral radiographs will help to assess thumb phalanges, metacarpal and carpometacarpal joint. One should assess wrist and forearm to rule out radial longitudinal deficiency.
As thumb hypoplasia can be associated with other syndromes, thorough cardiac, renal, haematological and musculoskeletal evaluation is essential. Common investigations include a complete blood count, 2D Echo Cardiogram and sonography abdomen for solid organs. This is important as the treatment of these conditions may take priority over thumb hypoplasia management. [12]Any positive findings may also impact anaesthesia for surgery.
Figure 4: Buck Gramcko type markings for dorsal side
Figure 5: Buck Gramcko type markings for palmar side
Figure 6: Dorsal flaps raised preserving dorsal venous network
Treatment
Aim of thumb reconstruction is to provide a functional and stable thumb which will improve the grip and aesthetic appearance of hand.
Typically Type I is more or less a functional thumb,hence no treatment is required.
Type II: depending on findings; first web space release, opponensplasty using Abductor Digiti Minimi (ADM) or other suitable donors and/or UCL reconstruction
Type III A: same procedures like type II and in addition may require further additional extrinsic tendon transfers to improve the function, which transfers and how needs to be decided on a case by case basis, depending on need.
Type IIIB,IIIC, IV and V: Pollicisation
Timing of surgery:
Surgery at an early age is recommended for better functional results as it will allow cognitive development and physiological adaptation of the reconstructed thumb before corticalisation which happens around 18 months of age. [13]
We are basically going to discuss about pollicisation in advanced hypoplasia IIIB onwards or Aplasia in this paper.
Pollicisation is a Latin word; Pollex means thumb and Pollicisation is defined as reconstruction of thumb using the adjacent radial finger.
History of pollicisation
In 1885,Guermonprez seems to be the first person to report a case of pollicisation. Before the second world war, many surgeons Dunlop (1923), Bunnell (1931) have reported doing pollicisation. However, follow up study of these cases had unsatisfactory results.
The major modification in the procedure was seen after the Second World War. Gosset (1949) [14] described index finger and ring finger pollicisation on neurovascular pedicle without skin attachments. Middle finger pollicisation was described by Hilgenfeldt (1950) [15]. Further contributions were by Bunnell (1952), Littler (1953). [16.17]
In 1971, Buck Gramcko published an article about pollicisation [18] which is the landmark article in establishing the technique of pollicisation in our opinion. Buck Gramcko’s major work on pollicisation evolved after the thalidomide tragedy in Europe which had led to many congenital hand and upper limb anomalies. Manske, Foucher et all have modified the technique but Buck Gramcko’s technique is the gold standard method still commonly used. The authors use the Buck Gramcko technique.
Principles of Pollicisation:
In 1990 Littler had said:
“It is not the full length of the thumb, nor its great strength and movement, but rather its strategic position relative to the fingers and the integrity of the specialized terminal pulp tissue which determines the prehensile status.”
Littler has classified requirements of the procedure as follows [19]
Mechanical
1. Correct length
2. Strategic position
3. Stability
Physiological
1. Movement
2. Sensibility
3. Absence of pain
4. Integration
Satisfactory appearance
In the opinion of the authors, pollicisation is one of the finest and most difficult operations in reconstructive hand surgery. Patient’s parents have a tough time deciding about amputing the useless thumb and using index finger for thumb reconstruction. Authors feel it is simultaneously rewarding to and taxing on the surgeon performing it. [20]
TECHNIQUE Figs. 1- 17
Fig. 1,2 and 3 represent pre operative photos and X-Ray.
Markings as per Buck-Gramcko (Fig. 4,5) Senior author (MRT) starts the surgery by raising the dorsal flaps taking care to preserve dorsal venous network. (Fig. 6)
Once the dorsal flaps are raised preserving dorsal venous network, palmar incisions are made and pedicles are dissected on the palmar side. Sometimes it may be required to open the neural ring on the ulnar side pedicle,if it is present.(Fig.7)
Figure 7: Dissection of vascular pedicles of Index finger
After dissecting and safeguarding the pedicle, first dorsal interosseous and first palmar interosseous with lateral band extension is identified and cut. To identify the distal lateral band at the time of final suturing, a 6-0 nylon suture is used for tagging the remaining lateral band (Fig. 8,9,10)
Figure 8: First dorsal interroseous raised with tendon
Figure 9: Lateral band on finger tagged with 6/0 nylon loose stitch for later identification
Figure 10: First palmar interroseous raised with tendon
Next step is to identify the two extensors – extensor indicis proprius and extensor digitorum communis of index finger and cut them. In more severe variants of Radial dysplasia only one tendon is present.(Fig. 11)
Figure 11: Extensor digitorum communis and Extensor Indicis proprious seen
Figure 12: Extensor Indicis proprious (EIP) cut and raised off MP joint so as to act on distal interphalangeal as future extensor pollicis longus
For setting the index completely free, the deep transverse metacarpal ligament between index and middle finger has to be divided. (Fig. 13)
Figure 13: Dividing deep transverse metacarpal ligament between index and middle finger
The line of division of metacarpal is through the epiphysis at the level of the head. The shaft is disarticulated at the CMC joint and is excised extra-periosteally.(Fig. 14,15)
Figure 14: Division of index finger metacarpal at the level of head of metacarpal
Figure 15: Metacarpal shaft disarticulated at carpometacarpal joint
At every step, one has to be careful about the neurovascular pedicle of the index finger.
The metacarpal head has to be rotated by 900 in extension and fixed with 4-0 nylon to prevent hyperextension of the new CMC joint.(Fig 16)
Figure 16: Rotating metacarpal head dorsally by 900
Index finger is now rotated 150 degrees, abducted 40-50 degrees and fixed at the CMC level with a 4-0 nylon suture which goes thru the CMC joint- head of metacarpal-CMC other lip.(Fig 17)
Figure 17: Index finger is fixed at CMC level
The Extensor/s are sutured first. The EIP becomes the EPL and the EDC becomes the APL
The Metacarpal level attachment of the EIP is dissected off; this enables the EIP to act on the DIP as an extensor. (Fig 12)
The EDC is kept attached at the base of the PPx of the IF so that once the tendon is reattached it acts as the APL.
The First dorsal interosseous is attached next to the lateral band to become the new abductor – opponens complex.(Fig. 18)
Figure 18: Suturing first dorsal interosseous to lateral band as the new abductor opponens complex
Dorsal flaps are sown.
The Palmar Interosseous is now attached to the other lateral band to become the Adductor Pollicis.
Skin flaps are now adjusted and closed to get the new thumb(Pollex) in opposition and pronation to achieve pulp to pulp pinch.(Fig. 19)
Fig. 20,21 show two views of the completed operation
Figure 19: Adjusting skin flaps to get new thumb in opposition and pronation
Figure 20: Final position palmar view
Figure 21: Final position dorsal view
A bulky padded dressing is given to protect the new thumb and tourniquet released and vascularity of both arteries and veins is checked.(Fig. 22)
Fig. 19 shows a long term result
Figure 22: Final dressing
Figure 23: showing 7 years follow up results
Complications of procedure
Losing the finger—very rare but possible
Skin necrosis
Hyperextension at CMC joint
Too long length
Functional Result may not be as good in severe radial longitudinal deficiency. There are chances of abnormalities of muscles of index finger and stiffness of index finger PIP joint in these cases (Symphalangism) which leads to relative functional impairment following pollicisation.
In our opinion it is still better than a four fingered hand at all times
Conclusion
Pollicisation is the optimum method of thumb reconstruction in thumb hypoplasia/aplasia
References
1. The rule of thumb by Tom Tyler JAC 30.3.4(2010) ,711-32.http://www.cyberchimp.co.uk/research/thumb.html
2. Lightdale-Miric N, Mueske NM, Lawrence EL, Loiselle J, Berggren J, Dayanidhi S, Stevanovic M, Valero-Cuevas FJ, Wren TA. Long term functional outcomes after early childhood pollicization. J Hand Ther. 2015 Apr-Jun;28(2):158-65
3. MahmutKömürcü, SerdarYüce et al. Index finger pollicization for treating a congenitally nonfunctioning thumb in patients with radial longitudinal deficiency. Eastern Journal of Medicine 2014;19: 175-181.
4. Tay SC, Moran SL, Shin AY, Cooney WC III. The hypoplastic thumb. J Am AcadOrthopSurg 2006;14: 354 –366.
5. Thumb hypoplasia .Scott A. Riley,Ronald C. Burgess. Hand Surg 2009;34A: 1564–1573.
6. James MA, McCarroll HR Jr, Manske PR. Characteristics of patients with hypoplastic thumbs. J Hand Surg 1996;21A: 104–113.
7. Abdel-Ghani B, Amro S. Characteristics of patients with hypoplastic thumb: a prospective study of 51 patients with the results of surgical treatment. J PediatrOrthop B 2004;13:127–138.
8. James MA, Green HD, McCarroll HR Jr, Manske PR. The association of radial deficiency with thumb hypoplasia. J Bone Joint Surg 2004;86A: 2196–2205.
9. Tickle C. Experimental embryology as applied to the upper limb. J Hand Surg 1987;12B: 294 –300.
10. Kato H, Ogino T, Minami A, Oshio I. Experimental study of radial ray deficiency. J Hand Surg 1990;15B:470–476.
11. Kozin SH. Deformities of the Thumb. Green’s Operative Hand Surgery.6 thed.ScottW.Wolfe, Robert N., William C., Scott K. editors. Philadelphia: Churchill Livingstone, Elsevier: 2011.p 1371.
12. Riley SA. An overview of radial longitudinal deficiency. CurrOrthop Prac2008;9:655–659.
13. Joseph Upton III and Amir Taghinia. Congenital hand III: Disorders of formation- thumb hypoplasia.James Chang and Peter C. Neliganeditors.Plastic Surgery- Hand and Upper Extremity.Elsevier Saunders,2013.p 572-602.
14. Gosset I: La pollicisation de I ‘index . J Chir.1949;65:403.
15. Bhaskaranand Kumar, Ashwath Acharya, and Anil K. Bhat. A relook at pollicization. Indian J Plast Surg. 2011 MayAug;44(2): 266–275.
16. Paul Binhammer and Graham Lister.Pollicization. Reconstructive Surgery in Hand Mutilation. Edited by Guy Foucher, Martin Dunitz: 1997.pg 29-40.
17. J W Littler, The neurovascular pedicle method of digital transposition for reconstruction of the thumb. Plast. Reconstr. Surg. 1953, 12:303-14
18. BuckGramcko D. Pollicization of the index finger. Method and results in aplasia and hypoplasia of the thumb. J Bone Joint Surg Am 1971;53:1605-17.
19. Yves Allieu, Michel Chammas and Jean Luc Roux. Considertions concerning pollicization. Reconstructive Surgery in Hand Mutilation. Edited by Guy Foucher, Martin Dunitz: 1997.pg41-52.
20. Thatte MR, Nehete S, Garude K, Mehta R. Unfavourable results in pollicisation. Indian J Plast Surg. 2013 May;46(2):303-11..
Dr Mukund R. Thatte
(Abstract) (Full Text HTML) (Download PDF)